Temporal trends of splenectomy in pediatric hospitalizations with immune thrombocytopenia

Neel S. Bhatt*, Parth Bhatt, Keyur Donda, Fredrick Dapaah-Siakwan, Riddhi Chaudhari, Vijay Gandhi Linga, Bhumi Patel, Anusha Lekshminarayanan, Smita Bhaskaran, Samer Zaid-Kaylani, Sherif M Badawy

*Corresponding author for this work

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Splenectomy is considered an effective treatment for immune thrombocytopenia (ITP) with 70–80% response rate. However, its current use is limited in children with ITP. It is unclear if the rates of splenectomy have changed over time. Using a large nationally representative database, we aimed to study the trends of splenectomy in pediatric hospitalizations with ITP, and the factors associated with splenectomy during these encounters. Methods: Using National (Nationwide) Inpatient Sample (NIS), and international classification of diseases (9th revision), clinical modification (ICD-9-CM) codes, we studied pediatric ITP hospitalizations with occurrence of total splenectomy between 2005 and 2014. Results: Out of 37,844 weighted ITP hospitalizations from 2005 to 2014; total splenectomy was performed in 954 encounters. Splenectomy rate declined over time (3.4% [2005–2006] to 1.6% [2013–2014], P < 0.001) with the younger age (≤5 years) having the most notable decline (0.91% [2005–2006] to 0.14% [2013–2014], P < 0.001). Splenectomy had higher odds of being performed electively than non-electively (odds ratio [OR]: 19.34, 95% confidence interval [CI]: 12.06–31.02, P < 0.001). Encounters with intracranial bleed were associated with the occurrence of splenectomy (OR: 17.87, 95% CI: 5.07–62.97, P < 0.001). Intracranial bleed (P < 0.001), gastrointestinal bleed (P < 0.01), sepsis (P < 0.001), and thrombosis (P < 0.001) were associated with longer length of stay and higher cost of hospitalization. Conclusions: Overall, splenectomy rates consistently declined over time. Intracranial hemorrhage during hospitalizations with ITP was associated with occurrence of splenectomy. Future studies should continue to reevaluate the rates of splenectomy in pediatric ITP in the presence of various second-line pharmacologic agents.

Original languageEnglish (US)
Article numbere27072
JournalPediatric Blood and Cancer
Volume65
Issue number7
DOIs
StatePublished - Jul 1 2018

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Idiopathic Thrombocytopenic Purpura
Splenectomy
Hospitalization
Pediatrics
Odds Ratio
Confidence Intervals
Intracranial Hemorrhages
Immunologic Factors
International Classification of Diseases
Inpatients
Length of Stay
Sepsis
Thrombosis

Keywords

  • NIS
  • immune thrombocytopenia
  • inpatient utilization
  • national inpatient sample
  • nationwide inpatient sample
  • splenectomy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

Bhatt, N. S., Bhatt, P., Donda, K., Dapaah-Siakwan, F., Chaudhari, R., Linga, V. G., ... Badawy, S. M. (2018). Temporal trends of splenectomy in pediatric hospitalizations with immune thrombocytopenia. Pediatric Blood and Cancer, 65(7), [e27072]. https://doi.org/10.1002/pbc.27072
Bhatt, Neel S. ; Bhatt, Parth ; Donda, Keyur ; Dapaah-Siakwan, Fredrick ; Chaudhari, Riddhi ; Linga, Vijay Gandhi ; Patel, Bhumi ; Lekshminarayanan, Anusha ; Bhaskaran, Smita ; Zaid-Kaylani, Samer ; Badawy, Sherif M. / Temporal trends of splenectomy in pediatric hospitalizations with immune thrombocytopenia. In: Pediatric Blood and Cancer. 2018 ; Vol. 65, No. 7.
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title = "Temporal trends of splenectomy in pediatric hospitalizations with immune thrombocytopenia",
abstract = "Background: Splenectomy is considered an effective treatment for immune thrombocytopenia (ITP) with 70–80{\%} response rate. However, its current use is limited in children with ITP. It is unclear if the rates of splenectomy have changed over time. Using a large nationally representative database, we aimed to study the trends of splenectomy in pediatric hospitalizations with ITP, and the factors associated with splenectomy during these encounters. Methods: Using National (Nationwide) Inpatient Sample (NIS), and international classification of diseases (9th revision), clinical modification (ICD-9-CM) codes, we studied pediatric ITP hospitalizations with occurrence of total splenectomy between 2005 and 2014. Results: Out of 37,844 weighted ITP hospitalizations from 2005 to 2014; total splenectomy was performed in 954 encounters. Splenectomy rate declined over time (3.4{\%} [2005–2006] to 1.6{\%} [2013–2014], P < 0.001) with the younger age (≤5 years) having the most notable decline (0.91{\%} [2005–2006] to 0.14{\%} [2013–2014], P < 0.001). Splenectomy had higher odds of being performed electively than non-electively (odds ratio [OR]: 19.34, 95{\%} confidence interval [CI]: 12.06–31.02, P < 0.001). Encounters with intracranial bleed were associated with the occurrence of splenectomy (OR: 17.87, 95{\%} CI: 5.07–62.97, P < 0.001). Intracranial bleed (P < 0.001), gastrointestinal bleed (P < 0.01), sepsis (P < 0.001), and thrombosis (P < 0.001) were associated with longer length of stay and higher cost of hospitalization. Conclusions: Overall, splenectomy rates consistently declined over time. Intracranial hemorrhage during hospitalizations with ITP was associated with occurrence of splenectomy. Future studies should continue to reevaluate the rates of splenectomy in pediatric ITP in the presence of various second-line pharmacologic agents.",
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author = "Bhatt, {Neel S.} and Parth Bhatt and Keyur Donda and Fredrick Dapaah-Siakwan and Riddhi Chaudhari and Linga, {Vijay Gandhi} and Bhumi Patel and Anusha Lekshminarayanan and Smita Bhaskaran and Samer Zaid-Kaylani and Badawy, {Sherif M}",
year = "2018",
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Bhatt, NS, Bhatt, P, Donda, K, Dapaah-Siakwan, F, Chaudhari, R, Linga, VG, Patel, B, Lekshminarayanan, A, Bhaskaran, S, Zaid-Kaylani, S & Badawy, SM 2018, 'Temporal trends of splenectomy in pediatric hospitalizations with immune thrombocytopenia', Pediatric Blood and Cancer, vol. 65, no. 7, e27072. https://doi.org/10.1002/pbc.27072

Temporal trends of splenectomy in pediatric hospitalizations with immune thrombocytopenia. / Bhatt, Neel S.; Bhatt, Parth; Donda, Keyur; Dapaah-Siakwan, Fredrick; Chaudhari, Riddhi; Linga, Vijay Gandhi; Patel, Bhumi; Lekshminarayanan, Anusha; Bhaskaran, Smita; Zaid-Kaylani, Samer; Badawy, Sherif M.

In: Pediatric Blood and Cancer, Vol. 65, No. 7, e27072, 01.07.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Temporal trends of splenectomy in pediatric hospitalizations with immune thrombocytopenia

AU - Bhatt, Neel S.

AU - Bhatt, Parth

AU - Donda, Keyur

AU - Dapaah-Siakwan, Fredrick

AU - Chaudhari, Riddhi

AU - Linga, Vijay Gandhi

AU - Patel, Bhumi

AU - Lekshminarayanan, Anusha

AU - Bhaskaran, Smita

AU - Zaid-Kaylani, Samer

AU - Badawy, Sherif M

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Background: Splenectomy is considered an effective treatment for immune thrombocytopenia (ITP) with 70–80% response rate. However, its current use is limited in children with ITP. It is unclear if the rates of splenectomy have changed over time. Using a large nationally representative database, we aimed to study the trends of splenectomy in pediatric hospitalizations with ITP, and the factors associated with splenectomy during these encounters. Methods: Using National (Nationwide) Inpatient Sample (NIS), and international classification of diseases (9th revision), clinical modification (ICD-9-CM) codes, we studied pediatric ITP hospitalizations with occurrence of total splenectomy between 2005 and 2014. Results: Out of 37,844 weighted ITP hospitalizations from 2005 to 2014; total splenectomy was performed in 954 encounters. Splenectomy rate declined over time (3.4% [2005–2006] to 1.6% [2013–2014], P < 0.001) with the younger age (≤5 years) having the most notable decline (0.91% [2005–2006] to 0.14% [2013–2014], P < 0.001). Splenectomy had higher odds of being performed electively than non-electively (odds ratio [OR]: 19.34, 95% confidence interval [CI]: 12.06–31.02, P < 0.001). Encounters with intracranial bleed were associated with the occurrence of splenectomy (OR: 17.87, 95% CI: 5.07–62.97, P < 0.001). Intracranial bleed (P < 0.001), gastrointestinal bleed (P < 0.01), sepsis (P < 0.001), and thrombosis (P < 0.001) were associated with longer length of stay and higher cost of hospitalization. Conclusions: Overall, splenectomy rates consistently declined over time. Intracranial hemorrhage during hospitalizations with ITP was associated with occurrence of splenectomy. Future studies should continue to reevaluate the rates of splenectomy in pediatric ITP in the presence of various second-line pharmacologic agents.

AB - Background: Splenectomy is considered an effective treatment for immune thrombocytopenia (ITP) with 70–80% response rate. However, its current use is limited in children with ITP. It is unclear if the rates of splenectomy have changed over time. Using a large nationally representative database, we aimed to study the trends of splenectomy in pediatric hospitalizations with ITP, and the factors associated with splenectomy during these encounters. Methods: Using National (Nationwide) Inpatient Sample (NIS), and international classification of diseases (9th revision), clinical modification (ICD-9-CM) codes, we studied pediatric ITP hospitalizations with occurrence of total splenectomy between 2005 and 2014. Results: Out of 37,844 weighted ITP hospitalizations from 2005 to 2014; total splenectomy was performed in 954 encounters. Splenectomy rate declined over time (3.4% [2005–2006] to 1.6% [2013–2014], P < 0.001) with the younger age (≤5 years) having the most notable decline (0.91% [2005–2006] to 0.14% [2013–2014], P < 0.001). Splenectomy had higher odds of being performed electively than non-electively (odds ratio [OR]: 19.34, 95% confidence interval [CI]: 12.06–31.02, P < 0.001). Encounters with intracranial bleed were associated with the occurrence of splenectomy (OR: 17.87, 95% CI: 5.07–62.97, P < 0.001). Intracranial bleed (P < 0.001), gastrointestinal bleed (P < 0.01), sepsis (P < 0.001), and thrombosis (P < 0.001) were associated with longer length of stay and higher cost of hospitalization. Conclusions: Overall, splenectomy rates consistently declined over time. Intracranial hemorrhage during hospitalizations with ITP was associated with occurrence of splenectomy. Future studies should continue to reevaluate the rates of splenectomy in pediatric ITP in the presence of various second-line pharmacologic agents.

KW - NIS

KW - immune thrombocytopenia

KW - inpatient utilization

KW - national inpatient sample

KW - nationwide inpatient sample

KW - splenectomy

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JF - Pediatric Blood and Cancer

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Bhatt NS, Bhatt P, Donda K, Dapaah-Siakwan F, Chaudhari R, Linga VG et al. Temporal trends of splenectomy in pediatric hospitalizations with immune thrombocytopenia. Pediatric Blood and Cancer. 2018 Jul 1;65(7). e27072. https://doi.org/10.1002/pbc.27072