Tenascin is overexpressed in vitiligo lesional skin and inhibits melanocyte adhesion

I. C. Le Poole*, R. M J G J Van Den Wijngaard, W. Westerhof, P. K. Das

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

The aetiology of vitiligo remains obscure. In this study, the role of integrins in the observed inability of melanocytes to repopulate lesional skin was investigated. Antibodies directed to α2, α3, α5, α(v), α6, β1 and β3 integrin subunits were used. Immunohistology revealed no marked differences in the overall levels of expression of integrins between control, non-lesional, perilesional or lesional skin. Moreover, no differences were noted in the level of expression of integrins or the adhesive capacity between cultured control cells derived from three separate donors and vitiligo-derived melanocytes from two donors. Rather, it was clearly observed that towards the lesion, vitiligo skin contains increasing amounts of tenascin in the basal membrane and papillary dermis in five patients employing T2H5 antihuman tenascin antibody. The anti-adhesive effect observed in vitro for this extracellular matrix molecule using normal melanocytes may contribute to loss of pigment cells in vitiligo or to ineffective repopulation of the lesions.

Original languageEnglish (US)
Pages (from-to)171-178
Number of pages8
JournalBritish Journal of Dermatology
Volume137
Issue number2
DOIs
StatePublished - 1997

ASJC Scopus subject areas

  • Dermatology

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