Tenecteplase for Stroke at 4.5 to 24 Hours with Perfusion-Imaging Selection

Gregory W. Albers*, Mouhammad Jumaa, Barbara Purdon, Syed F. Zaidi, Christopher Streib, Ashfaq Shuaib, Navdeep Sangha, Minjee Kim, Michael T. Froehler, Neil E. Schwartz, Wayne M. Clark, Charles E. Kircher, Ming Yang, Lori Massaro, Xiao Yu Lu, Gregory A. Rippon, Joseph P. Broderick, Ken Butcher, Maarten G. Lansberg, David S. LiebeskindAmre Nouh, Lee H. Schwamm, Bruce C.V. Campbell

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

BACKGROUND Thrombolytic agents, including tenecteplase, are generally used within 4.5 hours after the onset of stroke symptoms. Information on whether tenecteplase confers benefit beyond 4.5 hours is limited. METHODS We conducted a multicenter, double-blind, randomized, placebo-controlled trial involving patients with ischemic stroke to compare tenecteplase (0.25 mg per kilogram of body weight, up to 25 mg) with placebo administered 4.5 to 24 hours after the time that the patient was last known to be well. Patients had to have evidence of occlusion of the middle cerebral artery or internal carotid artery and salvageable tissue as determined on perfusion imaging. The primary outcome was the ordinal score on the modified Rankin scale (range, 0 to 6, with higher scores indicating greater disability and a score of 6 indicating death) at day 90. Safety outcomes included death and symptomatic intracranial hemorrhage. RESULTS The trial enrolled 458 patients, 77.3% of whom subsequently underwent thrombectomy; 228 patients were assigned to receive tenecteplase, and 230 to receive placebo. The median time between the time the patient was last known to be well and randomization was approximately 12 hours in the tenecteplase group and approximately 13 hours in the placebo group. The median score on the modified Rankin scale at 90 days was 3 in each group. The adjusted common odds ratio for the distribution of scores on the modified Rankin scale at 90 days for tenecteplase as compared with placebo was 1.13 (95% confidence interval, 0.82 to 1.57; P = 0.45). In the safety population, mortality at 90 days was 19.7% in the tenecteplase group and 18.2% in the placebo group, and the incidence of symptomatic intracranial hemorrhage was 3.2% and 2.3%, respectively. CONCLUSIONS Tenecteplase therapy that was initiated 4.5 to 24 hours after stroke onset in patients with occlusions of the middle cerebral artery or internal carotid artery, most of whom had undergone endovascular thrombectomy, did not result in better clinical outcomes than those with placebo. The incidence of symptomatic intracerebral hemorrhage was similar in the two groups.

Original languageEnglish (US)
Pages (from-to)701-711
Number of pages11
JournalNew England Journal of Medicine
Volume390
Issue number8
DOIs
StatePublished - Feb 22 2024

ASJC Scopus subject areas

  • General Medicine

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