Terminating Wnt signals: A novel nuclear export mechanism targets activated β-catenin

Meghan E. Thorne, Cara J. Gottardi*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Nuclear targeting of β-catenin is an obligatory step in Wnt signal transduction, but the factors that control import and export remain to be clarified. In this issue, Hendriksen et al. (p. 785) show that the RanBP3 export factor antagonizes β-catenin/T cell factor (TCF) transcription by targeting the signaling-competent form of β-catenin. We speculate that cells may use multiple export mechanisms to inhibit β-catenin signaling in different ways.

Original languageEnglish (US)
Pages (from-to)761-763
Number of pages3
JournalJournal of Cell Biology
Volume171
Issue number5
DOIs
StatePublished - Dec 5 2005

ASJC Scopus subject areas

  • Cell Biology

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