Test Characteristics of Cerebrospinal Fluid Gram Stain to Identify Bacterial Meningitis in Infants Younger Than 60 Days

Fran Balamuth; Andrea T. Cruz; Stephen B. Freedman; Paul T. Ishimine; Aris Garro; Sarah Curtis; Kendra L. Grether-Jones; Aaron S. Miller; Neil G. Uspal; Suzanne M. Schmidt; Samir S. Shah; Lise E. Nigrovic

doi:10.1097/PEC.0000000000001639

Test Characteristics of Cerebrospinal Fluid Gram Stain to Identify Bacterial Meningitis in Infants Younger Than 60 Days

Fran Balamuth^*, Andrea T. Cruz, Stephen B. Freedman, Paul T. Ishimine, Aris Garro, Sarah Curtis, Kendra L. Grether-Jones, Aaron S. Miller, Neil G. Uspal, Suzanne M. Schmidt, Samir S. Shah, Lise E. Nigrovic

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

In our cohort of 20,947 infants aged 60 days or younger, cerebrospinal fluid Gram stain had a sensitivity of 34.3% (95% confidence interval, 28.1%-41.1%) and a positive predictive value of 61.4% (95% confidence interval, 52.2%-69.8%) for positive cerebrospinal fluid culture, suggesting that Gram stain alone may lead to both underdiagnosis and overdiagnosis of bacterial meningitis.

Original language	English (US)
Pages (from-to)	E227-E229
Journal	Pediatric emergency care
Volume	37
Issue number	5
DOIs	https://doi.org/10.1097/PEC.0000000000001639
State	Published - 2021
Externally published	Yes

Keywords

cerebral spinal fluid Gram stain
infant
meningitis

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Emergency Medicine

Access to Document

10.1097/PEC.0000000000001639

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Balamuth, F., Cruz, A. T., Freedman, S. B., Ishimine, P. T., Garro, A., Curtis, S., Grether-Jones, K. L., Miller, A. S., Uspal, N. G., Schmidt, S. M., Shah, S. S., & Nigrovic, L. E. (2021). Test Characteristics of Cerebrospinal Fluid Gram Stain to Identify Bacterial Meningitis in Infants Younger Than 60 Days. Pediatric emergency care, 37(5), E227-E229. https://doi.org/10.1097/PEC.0000000000001639

Balamuth, Fran ; Cruz, Andrea T. ; Freedman, Stephen B. ; Ishimine, Paul T. ; Garro, Aris ; Curtis, Sarah ; Grether-Jones, Kendra L. ; Miller, Aaron S. ; Uspal, Neil G. ; Schmidt, Suzanne M. ; Shah, Samir S. ; Nigrovic, Lise E. / Test Characteristics of Cerebrospinal Fluid Gram Stain to Identify Bacterial Meningitis in Infants Younger Than 60 Days. In: Pediatric emergency care. 2021 ; Vol. 37, No. 5. pp. E227-E229.

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title = "Test Characteristics of Cerebrospinal Fluid Gram Stain to Identify Bacterial Meningitis in Infants Younger Than 60 Days",

abstract = "In our cohort of 20,947 infants aged 60 days or younger, cerebrospinal fluid Gram stain had a sensitivity of 34.3% (95% confidence interval, 28.1%-41.1%) and a positive predictive value of 61.4% (95% confidence interval, 52.2%-69.8%) for positive cerebrospinal fluid culture, suggesting that Gram stain alone may lead to both underdiagnosis and overdiagnosis of bacterial meningitis. ",

keywords = "cerebral spinal fluid Gram stain, infant, meningitis",

author = "Fran Balamuth and Cruz, {Andrea T.} and Freedman, {Stephen B.} and Ishimine, {Paul T.} and Aris Garro and Sarah Curtis and Grether-Jones, {Kendra L.} and Miller, {Aaron S.} and Uspal, {Neil G.} and Schmidt, {Suzanne M.} and Shah, {Samir S.} and Nigrovic, {Lise E.}",

year = "2021",

doi = "10.1097/PEC.0000000000001639",

language = "English (US)",

volume = "37",

pages = "E227--E229",

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Balamuth, F, Cruz, AT, Freedman, SB, Ishimine, PT, Garro, A, Curtis, S, Grether-Jones, KL, Miller, AS, Uspal, NG, Schmidt, SM, Shah, SS & Nigrovic, LE 2021, 'Test Characteristics of Cerebrospinal Fluid Gram Stain to Identify Bacterial Meningitis in Infants Younger Than 60 Days', Pediatric emergency care, vol. 37, no. 5, pp. E227-E229. https://doi.org/10.1097/PEC.0000000000001639

Test Characteristics of Cerebrospinal Fluid Gram Stain to Identify Bacterial Meningitis in Infants Younger Than 60 Days. / Balamuth, Fran; Cruz, Andrea T.; Freedman, Stephen B.; Ishimine, Paul T.; Garro, Aris; Curtis, Sarah; Grether-Jones, Kendra L.; Miller, Aaron S.; Uspal, Neil G.; Schmidt, Suzanne M.; Shah, Samir S.; Nigrovic, Lise E.

In: Pediatric emergency care, Vol. 37, No. 5, 2021, p. E227-E229.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Test Characteristics of Cerebrospinal Fluid Gram Stain to Identify Bacterial Meningitis in Infants Younger Than 60 Days

AU - Balamuth, Fran

AU - Cruz, Andrea T.

AU - Freedman, Stephen B.

AU - Ishimine, Paul T.

AU - Garro, Aris

AU - Curtis, Sarah

AU - Grether-Jones, Kendra L.

AU - Miller, Aaron S.

AU - Uspal, Neil G.

AU - Schmidt, Suzanne M.

AU - Shah, Samir S.

AU - Nigrovic, Lise E.

PY - 2021

Y1 - 2021

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AB - In our cohort of 20,947 infants aged 60 days or younger, cerebrospinal fluid Gram stain had a sensitivity of 34.3% (95% confidence interval, 28.1%-41.1%) and a positive predictive value of 61.4% (95% confidence interval, 52.2%-69.8%) for positive cerebrospinal fluid culture, suggesting that Gram stain alone may lead to both underdiagnosis and overdiagnosis of bacterial meningitis.

KW - cerebral spinal fluid Gram stain

KW - infant

KW - meningitis

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AN - SCOPUS:85105725647

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JO - Pediatric Emergency Care

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SN - 0749-5161

IS - 5

ER -

Test Characteristics of Cerebrospinal Fluid Gram Stain to Identify Bacterial Meningitis in Infants Younger Than 60 Days

Abstract

Keywords

ASJC Scopus subject areas

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