Test Characteristics of Cerebrospinal Fluid Gram Stain to Identify Bacterial Meningitis in Infants Younger Than 60 Days

Fran Balamuth*, Andrea T. Cruz, Stephen B. Freedman, Paul T. Ishimine, Aris Garro, Sarah Curtis, Kendra L. Grether-Jones, Aaron S. Miller, Neil G. Uspal, Suzanne M. Schmidt, Samir S. Shah, Lise E. Nigrovic

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

In our cohort of 20,947 infants aged 60 days or younger, cerebrospinal fluid Gram stain had a sensitivity of 34.3% (95% confidence interval, 28.1%-41.1%) and a positive predictive value of 61.4% (95% confidence interval, 52.2%-69.8%) for positive cerebrospinal fluid culture, suggesting that Gram stain alone may lead to both underdiagnosis and overdiagnosis of bacterial meningitis.

Original languageEnglish (US)
Pages (from-to)E227-E229
JournalPediatric emergency care
Volume37
Issue number5
DOIs
StatePublished - 2021
Externally publishedYes

Keywords

  • cerebral spinal fluid Gram stain
  • infant
  • meningitis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Emergency Medicine

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