Testicular tumors in prepubescent patients

Ilan I. Maizlin, Matthew Dellinger, Kenneth W. Gow, Adam B. Goldin, Melanie Goldfarb, Jed G. Nuchtern, Monica Langer, Sanjeev A. Vasudevan, John J. Doski, Mehul V Raval, Elizabeth A. Beierle*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Background/purpose: Pediatric testicular tumors are rare, constituting only 1% of all pediatric solid tumors. Single-institution studies addressing pediatric testicular tumors published to date have been limited in the number of patients. Methods: We utilized the National Cancer Data Base (1998–2012) to review all prepubescent patients (≤ 12 years old) with testicular neoplasms. Demographics, tumor characteristics, treatment modalities, and outcomes were abstracted. Results: A total of 479 patients were identified, with a median age of 3 years (IQR 0–4) at diagnosis. 67% of cases were diagnosed by 3 years of age. Yolk sac tumors were the most common histology (202 patients, 42.2%). Most tumors were diagnosed at a low stage. Resection was performed in 465 boys, with 75% having undergone radical orchiectomies. Chemotherapy was utilized in 28% of cases and radiotherapy in 7%. With mean follow-up of 5.6 years, mortality rate was 3%. No difference in mortality was noted based on histology or extent of surgical resection. Conclusions: This series of prepubertal testicular tumors is the largest yet reported and highlights the patient demographics, tumor characteristics, treatment modalities and outcomes for these tumors. Type of study: Prognosis study Level of evidence: II.

Original languageEnglish (US)
Pages (from-to)1748-1752
Number of pages5
JournalJournal of pediatric surgery
Issue number9
StatePublished - Sep 2018


  • Pediatrics
  • Prepubescent
  • Testes
  • Testicular neoplasm
  • Tumor

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

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