Testing for Coronary Artery Disease in Older Patients with New-Onset Heart Failure: Findings from Get with the Guidelines-Heart Failure

Kyle D. O'Connor, Todd Brophy, Gregg C. Fonarow, Ron Blankstein, Rajesh V. Swaminathan, Haolin Xu, Roland A. Matsouaka, Nancy M. Albert, Eric J. Velazquez, Clyde W. Yancy, Paul A. Heidenreich, Adrian F. Hernandez, Adam D. Devore*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Background: Current guidelines recommend evaluation for underlying heart disease and reversible conditions for patients with new-onset heart failure (HF). There are limited data on contemporary testing for coronary artery disease (CAD) in patients with new-onset HF. Methods: We performed an observational cohort study using the Get With The Guidelines-Heart Failure registry linked to Medicare claims. All patients were aged ≥65 and hospitalized for new-onset HF from 2009 to 2015. We collected left ventricular ejection fraction (LVEF), prior HF history, and in-hospital CAD testing from the registry, as well as testing for CAD using claims from 90 days before to 90 days after index HF hospitalization. Results: Among 17 185 patients with new-onset HF, 6672 (39%) received testing for CAD, including 3997 (23%) during the index hospitalization. Testing for CAD differed by LVEF: 53% in HF with reduced EF (LVEF ≤40%), 42% in HF with borderline EF (LVEF, 41%-49%), and 31% in HF with preserved EF (LVEF ≥50%). After multivariable adjustment, patients who received testing for CAD, compared with those who did not, were younger and more likely to be male, have a smoking history, have hyperlipidemia, and have HF with reduced ejection fraction or HF with borderline ejection fraction (all P<0.05). Conclusions: The majority of patients hospitalized for new-onset HF did not receive testing for CAD either during the hospitalization or in the 90 days before and after. The rates of testing for CAD were higher in patients with LVEF ≤40% though remained low. These data highlight an opportunity to improve care by identifying appropriate candidates for optimal CAD medical therapy and revascularization.

Original languageEnglish (US)
Article numbere006963
JournalCirculation: Heart Failure
StatePublished - Apr 1 2020


  • atrial fibrillation
  • coronary artery disease
  • heart failure
  • hyperlipidemia
  • left ventricular dysfunction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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