TY - JOUR
T1 - Testing for statistical significance in bispectra
T2 - A surrogate data approach and application to neuroscience
AU - Wang, Xue
AU - Chen, Yonghong
AU - Ding, Mingzhou
PY - 2007/11
Y1 - 2007/11
N2 - Interactions among neural signals in different frequency bands have become a focus of strong interest in neuroscience. Bispectral analysis, a type of higher order spectral analysis, provides us with the ability to investigate such nonlinear interactions. Based on the fact that the bispectrum of a linear Gaussian process is zero, a surrogate data method was proposed to test the null hypothesis that the original data were generated by a linear Gaussian process. The method was first tested on two simulation examples. It was then applied to local field potential recordings from a monkey performing a visuomotor task. The analysis reveals nonzero bispectra for beta and gamma band activities in the premotor cortex. The rigorous statistical framework proves essential in establishing these results.
AB - Interactions among neural signals in different frequency bands have become a focus of strong interest in neuroscience. Bispectral analysis, a type of higher order spectral analysis, provides us with the ability to investigate such nonlinear interactions. Based on the fact that the bispectrum of a linear Gaussian process is zero, a surrogate data method was proposed to test the null hypothesis that the original data were generated by a linear Gaussian process. The method was first tested on two simulation examples. It was then applied to local field potential recordings from a monkey performing a visuomotor task. The analysis reveals nonzero bispectra for beta and gamma band activities in the premotor cortex. The rigorous statistical framework proves essential in establishing these results.
KW - Bispectrum
KW - Local field potential
KW - Quadratic phase coupling (QPC)
KW - Surrogate data
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U2 - 10.1109/TBME.2007.895751
DO - 10.1109/TBME.2007.895751
M3 - Article
C2 - 18018692
AN - SCOPUS:35548955967
VL - 54
SP - 1974
EP - 1982
JO - IRE transactions on medical electronics
JF - IRE transactions on medical electronics
SN - 0018-9294
IS - 11
ER -