Testis specific lactate dehydrogenase as target for immunoliposomes

Ranjna C. Dutta*, Erwin Goldberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Problem: Is it possible to deliver therapeutic agents to testis through specific targeting? Method of study: Immunoliposomes are designed by incorporating antibodies to lactate dehydrogenase-C4 (LDH-C4), which is the product of a testis specific gene. Their targeting and delivering ability is investigated in vitro and in vivo. Results: It is observed that LDHC4-immunoliposomes are able to discriminate and recognize antigens on spermatozoa and testes both in vitro and in vivo. Conclusion: Specific targeting through LDH-C4 appears to be a feasible strategy for delivering therapeutic as well as anti-spermatogenic agents to testis.

Original languageEnglish (US)
Pages (from-to)26-32
Number of pages7
JournalAmerican Journal of Reproductive Immunology
Volume60
Issue number1
DOIs
StatePublished - Jul 1 2008

Keywords

  • Antispermatozoa
  • Contraception
  • Immunoliposomes
  • LDH-C
  • Sperms

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Reproductive Medicine
  • Obstetrics and Gynecology

Fingerprint Dive into the research topics of 'Testis specific lactate dehydrogenase as target for immunoliposomes'. Together they form a unique fingerprint.

Cite this