TY - JOUR
T1 - TGF-β-based immunotherapy for cancer
T2 - Breaching the tumor firewall
AU - Shah, Ali H.
AU - Lee, Chung
PY - 2000
Y1 - 2000
N2 - Many malignant cells secrete transforming growth factor-β (TGF-β), a potent immunosuppresant, suggesting that TGF-β production may represent a significant tumor escape mechanism from host immunosurveillance. Establishment of a leukocyte subpopulation with disrupted TGF-β signaling in the tumor-bearing host offers a potential means for immunotherapy of cancer. Downregulation of TGF-β secretion in tumor cells results in restoration of immunogenicity in the host, while T-cell insensitivity to TGF-β results in accelerated differentiation and autoimmunity, elements of which may be required in order to combat self-antigen-expressing tumors in a tolerized host. The rationale, approaches, and potential pitfalls of this strategy will be discussed. (C) 2000 Wiley-Liss, Inc.
AB - Many malignant cells secrete transforming growth factor-β (TGF-β), a potent immunosuppresant, suggesting that TGF-β production may represent a significant tumor escape mechanism from host immunosurveillance. Establishment of a leukocyte subpopulation with disrupted TGF-β signaling in the tumor-bearing host offers a potential means for immunotherapy of cancer. Downregulation of TGF-β secretion in tumor cells results in restoration of immunogenicity in the host, while T-cell insensitivity to TGF-β results in accelerated differentiation and autoimmunity, elements of which may be required in order to combat self-antigen-expressing tumors in a tolerized host. The rationale, approaches, and potential pitfalls of this strategy will be discussed. (C) 2000 Wiley-Liss, Inc.
KW - Immunotherapy
KW - Transforming growth factor-β
KW - Tumor immunosurveillance
UR - http://www.scopus.com/inward/record.url?scp=0033820365&partnerID=8YFLogxK
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U2 - 10.1002/1097-0045(20001001)45:2<167::AID-PROS11>3.0.CO;2-J
DO - 10.1002/1097-0045(20001001)45:2<167::AID-PROS11>3.0.CO;2-J
M3 - Review article
C2 - 11027416
AN - SCOPUS:0033820365
SN - 0270-4137
VL - 45
SP - 167
EP - 172
JO - Prostate
JF - Prostate
IS - 2
ER -
