TGF-β: Duality of function between tumor prevention and carcinogenesis

Daniel R. Principe, Jennifer A. Doll, Jessica Bauer, Barbara Jung, Hidayatullah G. Munshi, Laurent Bartholin, Boris Pasche, Chung Lee, Paul J. Grippo*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

249 Scopus citations

Abstract

Several mechanisms underlying tumor progression have remained elusive, particularly in relation to transforming growth factor beta (TGF-β). Although TGF-β initially inhibits epithelial growth, it appears to promote the progression of advanced tumors. Defects in normal TGF-β pathways partially explain this paradox, which can lead to a cascade of downstream events that drive multiple oncogenic pathways, manifesting as several key features of tumorigenesis (uncontrolled proliferation, loss of apoptosis, epithelial-to-mesenchymal transition, sustained angiogenesis, evasion of immune surveillance, and metastasis). Understanding the mechanisms of TGF-β dysregulation will likely reveal novel points of convergence between TGF-β and other pathways that can be specifically targeted for therapy.

Original languageEnglish (US)
JournalJournal of the National Cancer Institute
Volume106
Issue number2
DOIs
StatePublished - Feb 2014

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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