TGF-β mediated DNA methylation in prostate cancer

Chung Lee; Qiang Zhang; Xaolin Zi; Atreya Dash; Marcelo B. Soares; Farahnaz Rahmatpanah; Zhenyu Jia; Michael McClelland; Dan Mercola

doi:10.3978/j.issn.2223-4683.2012.05.06

TGF-β mediated DNA methylation in prostate cancer

Chung Lee^*, Qiang Zhang, Xaolin Zi, Atreya Dash, Marcelo B. Soares, Farahnaz Rahmatpanah, Zhenyu Jia, Michael McClelland, Dan Mercola

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

16 Scopus citations

Abstract

Almost all tumors harbor a defective negative feedback loop of signaling by transforming growth factor-β (TGF-β). Epigenetic mechanisms of gene regulation, including DNA methylation, are fundamental to normal cellular function and also play a major role in carcinogenesis. Recent evidence demonstrated that TGF-β signaling mediates cancer development and progression. Many key events in TGF-β signaling in cancer included auto-induction of TGF-β1 and increased expression of DNA methyltransferases (DNMTs), suggesting that DNA methylation plays a significant role in cancer development and progression. In this review, we performed an extensive survey of the literature linking TGF-β signaling to DNA methylation in prostate cancer. It appeared that almost all DNA methylated genes detected in prostate cancer are directly or indirectly related to TGF-β signaling. This knowledge has provided a basis for our future directions of prostate cancer research and strategies for prevention and therapy for prostate cancer.

Original language	English (US)
Pages (from-to)	78-88
Number of pages	11
Journal	Translational Andrology and Urology
Volume	1
Issue number	2
DOIs	https://doi.org/10.3978/j.issn.2223-4683.2012.05.06
State	Published - Jun 2012

Keywords

DNA methylation
DNMT
Erk activation
Prostate cancer
TGF-β
Tumor development and progression

ASJC Scopus subject areas

Urology
Reproductive Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3978/j.issn.2223-4683.2012.05.06

Cite this

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title = "TGF-β mediated DNA methylation in prostate cancer",

abstract = "Almost all tumors harbor a defective negative feedback loop of signaling by transforming growth factor-β (TGF-β). Epigenetic mechanisms of gene regulation, including DNA methylation, are fundamental to normal cellular function and also play a major role in carcinogenesis. Recent evidence demonstrated that TGF-β signaling mediates cancer development and progression. Many key events in TGF-β signaling in cancer included auto-induction of TGF-β1 and increased expression of DNA methyltransferases (DNMTs), suggesting that DNA methylation plays a significant role in cancer development and progression. In this review, we performed an extensive survey of the literature linking TGF-β signaling to DNA methylation in prostate cancer. It appeared that almost all DNA methylated genes detected in prostate cancer are directly or indirectly related to TGF-β signaling. This knowledge has provided a basis for our future directions of prostate cancer research and strategies for prevention and therapy for prostate cancer.",

keywords = "DNA methylation, DNMT, Erk activation, Prostate cancer, TGF-β, Tumor development and progression",

author = "Chung Lee and Qiang Zhang and Xaolin Zi and Atreya Dash and Soares, {Marcelo B.} and Farahnaz Rahmatpanah and Zhenyu Jia and Michael McClelland and Dan Mercola",

year = "2012",

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doi = "10.3978/j.issn.2223-4683.2012.05.06",

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T1 - TGF-β mediated DNA methylation in prostate cancer

AU - Lee, Chung

AU - Zhang, Qiang

AU - Zi, Xaolin

AU - Dash, Atreya

AU - Soares, Marcelo B.

AU - Rahmatpanah, Farahnaz

AU - Jia, Zhenyu

AU - McClelland, Michael

AU - Mercola, Dan

PY - 2012/6

Y1 - 2012/6

N2 - Almost all tumors harbor a defective negative feedback loop of signaling by transforming growth factor-β (TGF-β). Epigenetic mechanisms of gene regulation, including DNA methylation, are fundamental to normal cellular function and also play a major role in carcinogenesis. Recent evidence demonstrated that TGF-β signaling mediates cancer development and progression. Many key events in TGF-β signaling in cancer included auto-induction of TGF-β1 and increased expression of DNA methyltransferases (DNMTs), suggesting that DNA methylation plays a significant role in cancer development and progression. In this review, we performed an extensive survey of the literature linking TGF-β signaling to DNA methylation in prostate cancer. It appeared that almost all DNA methylated genes detected in prostate cancer are directly or indirectly related to TGF-β signaling. This knowledge has provided a basis for our future directions of prostate cancer research and strategies for prevention and therapy for prostate cancer.

AB - Almost all tumors harbor a defective negative feedback loop of signaling by transforming growth factor-β (TGF-β). Epigenetic mechanisms of gene regulation, including DNA methylation, are fundamental to normal cellular function and also play a major role in carcinogenesis. Recent evidence demonstrated that TGF-β signaling mediates cancer development and progression. Many key events in TGF-β signaling in cancer included auto-induction of TGF-β1 and increased expression of DNA methyltransferases (DNMTs), suggesting that DNA methylation plays a significant role in cancer development and progression. In this review, we performed an extensive survey of the literature linking TGF-β signaling to DNA methylation in prostate cancer. It appeared that almost all DNA methylated genes detected in prostate cancer are directly or indirectly related to TGF-β signaling. This knowledge has provided a basis for our future directions of prostate cancer research and strategies for prevention and therapy for prostate cancer.

KW - DNA methylation

KW - DNMT

KW - Erk activation

KW - Prostate cancer

KW - TGF-β

KW - Tumor development and progression

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DO - 10.3978/j.issn.2223-4683.2012.05.06

M3 - Review article

C2 - 25133096

AN - SCOPUS:84875441933

SN - 2223-4683

VL - 1

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JO - Translational Andrology and Urology

JF - Translational Andrology and Urology

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ER -

TGF-β mediated DNA methylation in prostate cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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