TGF-β mediated DNA methylation in prostate cancer

Chung Lee*, Qiang Zhang, Xaolin Zi, Atreya Dash, Marcelo B. Soares, Farahnaz Rahmatpanah, Zhenyu Jia, Michael McClelland, Dan Mercola

*Corresponding author for this work

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Almost all tumors harbor a defective negative feedback loop of signaling by transforming growth factor-β (TGF-β). Epigenetic mechanisms of gene regulation, including DNA methylation, are fundamental to normal cellular function and also play a major role in carcinogenesis. Recent evidence demonstrated that TGF-β signaling mediates cancer development and progression. Many key events in TGF-β signaling in cancer included auto-induction of TGF-β1 and increased expression of DNA methyltransferases (DNMTs), suggesting that DNA methylation plays a significant role in cancer development and progression. In this review, we performed an extensive survey of the literature linking TGF-β signaling to DNA methylation in prostate cancer. It appeared that almost all DNA methylated genes detected in prostate cancer are directly or indirectly related to TGF-β signaling. This knowledge has provided a basis for our future directions of prostate cancer research and strategies for prevention and therapy for prostate cancer.

Original languageEnglish (US)
Pages (from-to)78-88
Number of pages11
JournalTranslational Andrology and Urology
Volume1
Issue number2
DOIs
StatePublished - Jan 1 2012

Keywords

  • DNA methylation
  • DNMT
  • Erk activation
  • Prostate cancer
  • TGF-β
  • Tumor development and progression

ASJC Scopus subject areas

  • Reproductive Medicine
  • Urology

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  • Cite this

    Lee, C., Zhang, Q., Zi, X., Dash, A., Soares, M. B., Rahmatpanah, F., Jia, Z., McClelland, M., & Mercola, D. (2012). TGF-β mediated DNA methylation in prostate cancer. Translational Andrology and Urology, 1(2), 78-88. https://doi.org/10.3978/j.issn.2223-4683.2012.05.06