TGF-β signal transduction and mesangial cell fibrogenesis

H. William Schnaper*, Tomoko Hayashida, Susan C. Hubchak, Anne Christine Poncelet

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

287 Scopus citations

Abstract

Transforming growth factor-β (TGF-β) is closely associated with progressive renal fibrosis. Significant progress has been accomplished in determining the cellular signaling pathways that are activated by TGF-β. This knowledge is being applied to glomerular mesangial cell models of extracellular matrix (ECM) accumulation. A central component of TGF-β-stimulated mesangial cell fibrogenesis is the TGF-β family-specific Smad signal transduction pathway. However, while Smads play an important role in collagen accumulation, recent findings indicate that cross talk among a variety of pathways is necessary for maximal stimulation of collagen expression. Further investigation of these multiple interactions will provide insight into possible ways to interrupt cellular mechanisms of glomerular fibrogenesis.

Original languageEnglish (US)
Pages (from-to)F243-F252
JournalAmerican Journal of Physiology - Renal Physiology
Volume284
Issue number2 53-2
DOIs
StatePublished - Feb 1 2003

Keywords

  • Glomerulosclerosis
  • Smads
  • Transforming growth factor-β

ASJC Scopus subject areas

  • Physiology
  • Urology

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