TGF-beta signal transduction in chronic kidney disease

H. William Schnaper; Sara Jandeska; Constance E. Runyan; Susan C. Hubchak; Rajit K. Basu; Jessica F. Curley; Ronald D. Smith; Tomoko Hayashida

doi:10.2741/3389

TGF-beta signal transduction in chronic kidney disease

H. William Schnaper, Sara Jandeska, Constance E. Runyan, Susan C. Hubchak, Rajit K. Basu, Jessica F. Curley, Ronald D. Smith, Tomoko Hayashida

Pediatrics

Research output: Contribution to journal › Article › peer-review

107 Scopus citations

Abstract

Transforming growth factor (TGF)-beta is a central stimulus of the events leading to chronic progressive kidney disease, having been implicated in the regulation of cell proliferation, hypertrophy, apoptosis and fibrogenesis. The fact that it mediates these varied events suggests that multiple mechanisms play a role in determining the outcome of TGF-beta signaling. Regulation begins with the availability and activation of TGF-beta and continues through receptor expression and localization, control of the TGF-beta family-specific Smad signaling proteins, and interaction of the Smads with multiple signaling pathways extending into the nucleus. Studies of these mechanisms in kidney cells and in wholeanimal experimental models, reviewed here, are beginning to provide insight into the role of TGF-beta in the pathogenesis of renal dysfunction and its potential treatment.

Original language	English (US)
Pages (from-to)	2448-2465
Number of pages	18
Journal	Frontiers in Bioscience
Volume	14
Issue number	7
DOIs	https://doi.org/10.2741/3389
State	Published - Jan 1 2009

Keywords

Cross-talk
Fibrosis
Review
Signal transduction
Smad
TGF-beta

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Immunology and Microbiology(all)

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10.2741/3389

Cite this

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AU - Runyan, Constance E.

AU - Hubchak, Susan C.

AU - Basu, Rajit K.

AU - Curley, Jessica F.

AU - Smith, Ronald D.

AU - Hayashida, Tomoko

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TGF-beta signal transduction in chronic kidney disease

Abstract

Keywords

ASJC Scopus subject areas

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