TGFBR1*6A is not associated with prostate cancer in men of European ancestry

B. K. Suarez; P. Pal; C. H. Jin; R. Kaushal; G. Sun; L. Jin; B. Pasche; R. Deka; W. J. Catalona

doi:10.1038/sj.pcan.4500765

TGFBR1*6A is not associated with prostate cancer in men of European ancestry

B. K. Suarez^*, P. Pal, C. H. Jin, R. Kaushal, G. Sun, L. Jin, B. Pasche, R. Deka, W. J. Catalona

^*Corresponding author for this work

Urology

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The TGFBR1*6A (*6A) variant in exon 1 of the TGFBR1 gene has been postulated as a putative tumor susceptibility allele in several studies. We have performed a case -control study in 537 men with histologically verified prostate cancer and in 488 unrelated controls to investigate the association of *6A with prostate cancer. Our results revealed that the frequency of the *6A allele does not differ in men with prostate cancer compared to healthy controls, even in a subset of age-matched cases and controls. There is no compelling evidence for an association of the *6A variant with prostate cancer.

Original language	English (US)
Pages (from-to)	50-53
Number of pages	4
Journal	Prostate Cancer and Prostatic Diseases
Volume	8
Issue number	1
DOIs	https://doi.org/10.1038/sj.pcan.4500765
State	Published - Mar 2005

Keywords

Association
TGFBR1

ASJC Scopus subject areas

Oncology
Urology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/sj.pcan.4500765

Cite this

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title = "TGFBR1*6A is not associated with prostate cancer in men of European ancestry",

abstract = "The TGFBR1*6A (*6A) variant in exon 1 of the TGFBR1 gene has been postulated as a putative tumor susceptibility allele in several studies. We have performed a case -control study in 537 men with histologically verified prostate cancer and in 488 unrelated controls to investigate the association of *6A with prostate cancer. Our results revealed that the frequency of the *6A allele does not differ in men with prostate cancer compared to healthy controls, even in a subset of age-matched cases and controls. There is no compelling evidence for an association of the *6A variant with prostate cancer.",

keywords = "Association, TGFBR1",

author = "Suarez, {B. K.} and P. Pal and Jin, {C. H.} and R. Kaushal and G. Sun and L. Jin and B. Pasche and R. Deka and Catalona, {W. J.}",

note = "Funding Information: This work was supported by an award from the Urological Research Foundation, St Louis.",

year = "2005",

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doi = "10.1038/sj.pcan.4500765",

language = "English (US)",

volume = "8",

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journal = "Prostate Cancer and Prostatic Diseases",

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T1 - TGFBR1*6A is not associated with prostate cancer in men of European ancestry

AU - Suarez, B. K.

AU - Pal, P.

AU - Jin, C. H.

AU - Kaushal, R.

AU - Sun, G.

AU - Jin, L.

AU - Pasche, B.

AU - Deka, R.

AU - Catalona, W. J.

N1 - Funding Information: This work was supported by an award from the Urological Research Foundation, St Louis.

PY - 2005/3

Y1 - 2005/3

N2 - The TGFBR1*6A (*6A) variant in exon 1 of the TGFBR1 gene has been postulated as a putative tumor susceptibility allele in several studies. We have performed a case -control study in 537 men with histologically verified prostate cancer and in 488 unrelated controls to investigate the association of *6A with prostate cancer. Our results revealed that the frequency of the *6A allele does not differ in men with prostate cancer compared to healthy controls, even in a subset of age-matched cases and controls. There is no compelling evidence for an association of the *6A variant with prostate cancer.

AB - The TGFBR1*6A (*6A) variant in exon 1 of the TGFBR1 gene has been postulated as a putative tumor susceptibility allele in several studies. We have performed a case -control study in 537 men with histologically verified prostate cancer and in 488 unrelated controls to investigate the association of *6A with prostate cancer. Our results revealed that the frequency of the *6A allele does not differ in men with prostate cancer compared to healthy controls, even in a subset of age-matched cases and controls. There is no compelling evidence for an association of the *6A variant with prostate cancer.

KW - Association

KW - TGFBR1

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DO - 10.1038/sj.pcan.4500765

M3 - Article

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AN - SCOPUS:20444497328

SN - 1365-7852

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JO - Prostate Cancer and Prostatic Diseases

JF - Prostate Cancer and Prostatic Diseases

IS - 1

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TGFBR1*6A is not associated with prostate cancer in men of European ancestry

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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