Abstract
Although developmental outcomes may improve following functional hemispherotomy for lateralized, catastrophic childhood epilepsy, the neuronal processes mediating these improvements are unknown. We report the case of a 14-year-old child with neurocognitive impairment who underwent functional hemispherotomy with longitudinal resting-state fMRI. Compared with preoperative fMRI, we report significantly more robust thalamo-default mode network connectivity on postoperative neuroimaging. Furthermore, we show decreased connectivity to nodes within the disconnected hemisphere, providing direct evidence that functional interactions are dependent upon structural connectivity. Since the vascular supply to these nodes remains intact, although they are disconnected from the remainder of the brain, these findings also confirm that blood-oxygen level dependent oscillations are driven primarily by neuronal activity. The current study highlights the importance of thalamocortical interactions in the understanding of neural oscillations and cognitive function, and their impairment in childhood epilepsy.
Original language | English (US) |
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Pages (from-to) | 281-285 |
Number of pages | 5 |
Journal | Epilepsy and Behavior |
Volume | 51 |
DOIs | |
State | Published - Oct 1 2015 |
Funding
This research was supported by the Canadian Institutes of Health Research (CIHR) Vanier Canada Graduate Scholarship , CIHR Bisby Fellowship , The Hospital for Sick Children Foundation Student Scholarship Program , the Wiley Family and Jack Beqaj Funds for Epilepsy Surgery Research , and the University of Toronto Surgeon-Scientist Program .
Keywords
- Epilepsy
- Functional connectivity
- Hemispherectomy
- Oscillations
- Peri-insular hemispherotomy
- Resting-state fMRI
- Thalamocortical oscillations
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
- Behavioral Neuroscience