Thalassemias

Alissa Martin, Alexis A Thompson*

*Corresponding author for this work

Research output: Contribution to journalReview article

37 Citations (Scopus)

Abstract

The thalassemia syndromes are hemoglobin disorders that result from significantly reduced or absent synthesis of either the α- or β-globin chains. The result is a chronic hemolytic anemia with ineffective erythropoiesis and bone marrow overstimulation. This article reviews current diagnostic approaches, complications, and disease management of thalassemia.

Original languageEnglish (US)
Pages (from-to)1383-1391
Number of pages9
JournalPediatric Clinics of North America
Volume60
Issue number6
DOIs
StatePublished - Dec 1 2013

Fingerprint

Thalassemia
Globins
Erythropoiesis
Hemolytic Anemia
Disease Management
Hemoglobins
Bone Marrow

Keywords

  • Anemia
  • Hemoglobinopathies
  • Iron overload
  • Thalassemia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Martin, Alissa ; Thompson, Alexis A. / Thalassemias. In: Pediatric Clinics of North America. 2013 ; Vol. 60, No. 6. pp. 1383-1391.
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Thalassemias. / Martin, Alissa; Thompson, Alexis A.

In: Pediatric Clinics of North America, Vol. 60, No. 6, 01.12.2013, p. 1383-1391.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Thalassemias

AU - Martin, Alissa

AU - Thompson, Alexis A

PY - 2013/12/1

Y1 - 2013/12/1

N2 - The thalassemia syndromes are hemoglobin disorders that result from significantly reduced or absent synthesis of either the α- or β-globin chains. The result is a chronic hemolytic anemia with ineffective erythropoiesis and bone marrow overstimulation. This article reviews current diagnostic approaches, complications, and disease management of thalassemia.

AB - The thalassemia syndromes are hemoglobin disorders that result from significantly reduced or absent synthesis of either the α- or β-globin chains. The result is a chronic hemolytic anemia with ineffective erythropoiesis and bone marrow overstimulation. This article reviews current diagnostic approaches, complications, and disease management of thalassemia.

KW - Anemia

KW - Hemoglobinopathies

KW - Iron overload

KW - Thalassemia

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DO - 10.1016/j.pcl.2013.08.008

M3 - Review article

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VL - 60

SP - 1383

EP - 1391

JO - Pediatric Clinics of North America

JF - Pediatric Clinics of North America

SN - 0031-3955

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