Thalassemias

Alissa Martin, Alexis A. Thompson*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

51 Scopus citations

Abstract

The thalassemia syndromes are hemoglobin disorders that result from significantly reduced or absent synthesis of either the α- or β-globin chains. The result is a chronic hemolytic anemia with ineffective erythropoiesis and bone marrow overstimulation. This article reviews current diagnostic approaches, complications, and disease management of thalassemia.

Original languageEnglish (US)
Pages (from-to)1383-1391
Number of pages9
JournalPediatric Clinics of North America
Volume60
Issue number6
DOIs
StatePublished - Dec 2013

Keywords

  • Anemia
  • Hemoglobinopathies
  • Iron overload
  • Thalassemia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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