TY - JOUR
T1 - The β form of the estrogen receptor is predominantly expressed in the papillary cystic neoplasm of the pancreas
AU - Morales, Angélica
AU - Duarte-Rojo, Andrés
AU - Ángeles-Ángeles, Arturo
AU - Mery, Carlos M.
AU - Ruíz-Molina, Juan M.
AU - Díaz-Sánchez, Vicente
AU - Robles-Díaz, Guillermo
PY - 2003/4
Y1 - 2003/4
N2 - Introduction: Papillary cystic neoplasm (PCN) of the pancreas is a low-malignancy tumor affecting predominantly young females. Sex steroid hormones have been involved in its development and/or growth. Estrogen receptor (ER) has been scarcely found in this tumor, although there is some evidence suggesting expression of the beta-isoform. Unlike ER, progesterone receptor (PR) expression has been consistently observed. Immunohistochemical analysis of the two isoforms of ER has not been performed in this tumor. Aim: To characterize expression of ER isoforms with an immunohistochemical method. Methodology: Expression of ERalpha, ER-beta, and PR was analyzed by immunohistochemistry using isoform-specific ER and PR antibodies in paraffinembedded tissue blocks from seven cases of PCN of the pancreas. Results: Most patients were young females. ER-alpha and ERbeta were present in two and six tumors, respectively. PR was identified in six tumors. Conclusions: ER-beta expression predominates over the alpha-isoform in PCN of the pancreas. This finding supports the idea that previous negative results on ER expression were a consequence of the use of antibodies with no anti-beta activity. The role of ER-beta in the milieu of factors promoting the development and aggressiveness of PCN needs to be elucidated to address novel diagnostic and therapeutic approaches.
AB - Introduction: Papillary cystic neoplasm (PCN) of the pancreas is a low-malignancy tumor affecting predominantly young females. Sex steroid hormones have been involved in its development and/or growth. Estrogen receptor (ER) has been scarcely found in this tumor, although there is some evidence suggesting expression of the beta-isoform. Unlike ER, progesterone receptor (PR) expression has been consistently observed. Immunohistochemical analysis of the two isoforms of ER has not been performed in this tumor. Aim: To characterize expression of ER isoforms with an immunohistochemical method. Methodology: Expression of ERalpha, ER-beta, and PR was analyzed by immunohistochemistry using isoform-specific ER and PR antibodies in paraffinembedded tissue blocks from seven cases of PCN of the pancreas. Results: Most patients were young females. ER-alpha and ERbeta were present in two and six tumors, respectively. PR was identified in six tumors. Conclusions: ER-beta expression predominates over the alpha-isoform in PCN of the pancreas. This finding supports the idea that previous negative results on ER expression were a consequence of the use of antibodies with no anti-beta activity. The role of ER-beta in the milieu of factors promoting the development and aggressiveness of PCN needs to be elucidated to address novel diagnostic and therapeutic approaches.
KW - Estrogen receptor
KW - Immunohistochemistry
KW - Pancreatic neoplasms
KW - Papillary cystic neoplasm
KW - Progesterone receptor
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U2 - 10.1097/00006676-200304000-00009
DO - 10.1097/00006676-200304000-00009
M3 - Article
C2 - 12657952
AN - SCOPUS:12244283702
SN - 0885-3177
VL - 26
SP - 258
EP - 263
JO - Pancreas
JF - Pancreas
IS - 3
ER -