The β3-adrenergic receptor gene and obesity in a population sample of African Americans

W. L. Lowe*, C. N. Rotimi, A. Luke, X. Guo, X. Zhu, A. G. Comuzzie, T. S. Schuh, S. Halbach, T. J. Kotlar, R. S. Cooper

*Corresponding author for this work

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

OBJECTIVE: To examine the role of the Trp64Arg polymorphism in the β3-adrenergic receptor gene and the β3-adrenergic receptor gene locus in obesity-related traits in African Americans. SUBJECTS: A total of 687 individuals representing 193 African American families who were residents of metropolitan Chicago. MEASUREMENTS: Genotyping of the Trp64Arg polymorphism in the β3-adrenergic receptor gene and three microsatellite markers flanking the β3-adrenergic receptor gene (ADRB3) locus and measuring various obesity-related traits, including body mass index (BMI), fat-free mass, fat mass, percentage fat mass, waist circumference and serum lipid levels. RESULTS: The prevalence of obesity (defined as body mass index ≥30 kg/m2) in the population was 27.3% and 51.2% in men and women, respectively. The frequency of the Arg64 allele was 10.0%. Multivariate regression analyses confirmed the existence of a significant contribution of familial variance to each of the five obesity-related traits noted above. Likelihood ratio statistics computed in a multivariate regression analysis failed to demonstrate a significant association between the Arg64 allele and any of the five obesity-related traits. Single and multipoint analyses using extended Haseman-Elston regression analyses failed to demonstrate suggestive evidence of linkage of three microsatellite markers that flank the β3-adrenergic receptor gene to BMI, percentage body fat, waist circumference or serum leptin levels. CONCLUSION: Given the contribution of familial variance to obesity-related traits in this population, neither the null finding for the Arg64 allele nor the lack of evidence of linkage of the ADRB3 locus to obesity-related traits could be attributed to lack of transmissibility of the traits suggesting that neither the Arg64 variant of the β3-adrenergic receptor gene nor another genetic variant in or near the ADRB3 locus contribute significantly to familial aggregation of obesity-related traits in African Americans.

Original languageEnglish (US)
Pages (from-to)54-60
Number of pages7
JournalInternational Journal of Obesity
Volume25
Issue number1
DOIs
StatePublished - Feb 20 2001

Keywords

  • African American
  • Genetics
  • Leptin
  • β3-adrenergic receptor

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

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    Lowe, W. L., Rotimi, C. N., Luke, A., Guo, X., Zhu, X., Comuzzie, A. G., Schuh, T. S., Halbach, S., Kotlar, T. J., & Cooper, R. S. (2001). The β3-adrenergic receptor gene and obesity in a population sample of African Americans. International Journal of Obesity, 25(1), 54-60. https://doi.org/10.1038/sj.ijo.0801487