The -1030/-862-linked TNF promoter single-nucleotide polymorphisms are associated with the inability to control HIV-1 viremia

Julio C. Delgado; Jessica Y. Leung; Andres Baena; Olga P. Clavijo; Eric Vittinghoff; Susan Buchbinder; Steven Wolinsky; Marilynn Addo; Bruce D. Walker; Edmond J. Yunis; Anne E. Goldfeld

doi:10.1007/s00251-003-0604-7

The -1030/-862-linked TNF promoter single-nucleotide polymorphisms are associated with the inability to control HIV-1 viremia

Julio C. Delgado, Jessica Y. Leung, Andres Baena, Olga P. Clavijo, Eric Vittinghoff, Susan Buchbinder, Steven Wolinsky, Marilynn Addo, Bruce D. Walker, Edmond J. Yunis, Anne E. Goldfeld^*

^*Corresponding author for this work

Medicine, Infectious Diseases Division

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12 Scopus citations

Abstract

Control of HIV-1 viremia and progression to AIDS has been associated with specific HLA genes. The tumor necrosis factor (TNF) and the non-classical major histocompatibility (MHC) class I chain-related A (MICA) genes are located in the genomic segment between the HLA class I and II genes and variants of both genes have been identified. We thus analyzed TNF promoter and MICA variants in a well-characterized group of HIV-1 infected individuals with different abilities to control HIV-1 viremia. In our cohort, the -1030/-862-linked TNF promoter single-nucleotide polymorphisms (SNPs), but not MICA variants, are significantly associated with lack of control of HIV-1 viremia (P=0.03). This association is independent of those HLA-B35 alleles associated with HIV-1 disease progression with which the -862 TNF SNP has previously been independently associated. Thus, non-randomly associated genes near the TNF locus are likely involved in control of HIV-1 viremia.

Original language	English (US)
Pages (from-to)	497-501
Number of pages	5
Journal	Immunogenetics
Volume	55
Issue number	7
DOIs	https://doi.org/10.1007/s00251-003-0604-7
State	Published - Oct 2003

ASJC Scopus subject areas

Immunology
Genetics

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Delgado, Julio C. ; Leung, Jessica Y. ; Baena, Andres ; Clavijo, Olga P. ; Vittinghoff, Eric ; Buchbinder, Susan ; Wolinsky, Steven ; Addo, Marilynn ; Walker, Bruce D. ; Yunis, Edmond J. ; Goldfeld, Anne E. / The -1030/-862-linked TNF promoter single-nucleotide polymorphisms are associated with the inability to control HIV-1 viremia. In: Immunogenetics. 2003 ; Vol. 55, No. 7. pp. 497-501.

@article{d4b8dcc910644c9aa533ba7621efdcc2,

title = "The -1030/-862-linked TNF promoter single-nucleotide polymorphisms are associated with the inability to control HIV-1 viremia",

abstract = "Control of HIV-1 viremia and progression to AIDS has been associated with specific HLA genes. The tumor necrosis factor (TNF) and the non-classical major histocompatibility (MHC) class I chain-related A (MICA) genes are located in the genomic segment between the HLA class I and II genes and variants of both genes have been identified. We thus analyzed TNF promoter and MICA variants in a well-characterized group of HIV-1 infected individuals with different abilities to control HIV-1 viremia. In our cohort, the -1030/-862-linked TNF promoter single-nucleotide polymorphisms (SNPs), but not MICA variants, are significantly associated with lack of control of HIV-1 viremia (P=0.03). This association is independent of those HLA-B35 alleles associated with HIV-1 disease progression with which the -862 TNF SNP has previously been independently associated. Thus, non-randomly associated genes near the TNF locus are likely involved in control of HIV-1 viremia.",

author = "Delgado, {Julio C.} and Leung, {Jessica Y.} and Andres Baena and Clavijo, {Olga P.} and Eric Vittinghoff and Susan Buchbinder and Steven Wolinsky and Marilynn Addo and Walker, {Bruce D.} and Yunis, {Edmond J.} and Goldfeld, {Anne E.}",

note = "Funding Information: Acknowledgements This work was supported by grants from the NIH (HL-59838 to A.E.G), (AI-28568 to B.D.W), and (HL-67471 to J.C.D.) and from the American Heart Association to A.E.G. We thank Eric Rosenberg, Spyros Kalams, Stephen Boswell and James Braun for providing valuable samples.",

year = "2003",

month = oct,

doi = "10.1007/s00251-003-0604-7",

language = "English (US)",

volume = "55",

pages = "497--501",

journal = "Immunogenetics",

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number = "7",

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The -1030/-862-linked TNF promoter single-nucleotide polymorphisms are associated with the inability to control HIV-1 viremia. / Delgado, Julio C.; Leung, Jessica Y.; Baena, Andres; Clavijo, Olga P.; Vittinghoff, Eric; Buchbinder, Susan; Wolinsky, Steven; Addo, Marilynn; Walker, Bruce D.; Yunis, Edmond J.; Goldfeld, Anne E.

In: Immunogenetics, Vol. 55, No. 7, 10.2003, p. 497-501.

Research output: Contribution to journal › Article › peer-review

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T1 - The -1030/-862-linked TNF promoter single-nucleotide polymorphisms are associated with the inability to control HIV-1 viremia

AU - Delgado, Julio C.

AU - Leung, Jessica Y.

AU - Baena, Andres

AU - Clavijo, Olga P.

AU - Vittinghoff, Eric

AU - Buchbinder, Susan

AU - Wolinsky, Steven

AU - Addo, Marilynn

AU - Walker, Bruce D.

AU - Yunis, Edmond J.

AU - Goldfeld, Anne E.

N1 - Funding Information: Acknowledgements This work was supported by grants from the NIH (HL-59838 to A.E.G), (AI-28568 to B.D.W), and (HL-67471 to J.C.D.) and from the American Heart Association to A.E.G. We thank Eric Rosenberg, Spyros Kalams, Stephen Boswell and James Braun for providing valuable samples.

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N2 - Control of HIV-1 viremia and progression to AIDS has been associated with specific HLA genes. The tumor necrosis factor (TNF) and the non-classical major histocompatibility (MHC) class I chain-related A (MICA) genes are located in the genomic segment between the HLA class I and II genes and variants of both genes have been identified. We thus analyzed TNF promoter and MICA variants in a well-characterized group of HIV-1 infected individuals with different abilities to control HIV-1 viremia. In our cohort, the -1030/-862-linked TNF promoter single-nucleotide polymorphisms (SNPs), but not MICA variants, are significantly associated with lack of control of HIV-1 viremia (P=0.03). This association is independent of those HLA-B35 alleles associated with HIV-1 disease progression with which the -862 TNF SNP has previously been independently associated. Thus, non-randomly associated genes near the TNF locus are likely involved in control of HIV-1 viremia.

AB - Control of HIV-1 viremia and progression to AIDS has been associated with specific HLA genes. The tumor necrosis factor (TNF) and the non-classical major histocompatibility (MHC) class I chain-related A (MICA) genes are located in the genomic segment between the HLA class I and II genes and variants of both genes have been identified. We thus analyzed TNF promoter and MICA variants in a well-characterized group of HIV-1 infected individuals with different abilities to control HIV-1 viremia. In our cohort, the -1030/-862-linked TNF promoter single-nucleotide polymorphisms (SNPs), but not MICA variants, are significantly associated with lack of control of HIV-1 viremia (P=0.03). This association is independent of those HLA-B35 alleles associated with HIV-1 disease progression with which the -862 TNF SNP has previously been independently associated. Thus, non-randomly associated genes near the TNF locus are likely involved in control of HIV-1 viremia.

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The -1030/-862-linked TNF promoter single-nucleotide polymorphisms are associated with the inability to control HIV-1 viremia

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