TY - JOUR
T1 - The 5 Ps of acute ischemic stroke treatment
T2 - Parenchyma, pipes, perfusion, penumbra, and prevention of complications
AU - Felberg, Robert A.
AU - Naidech, Andrew M.
PY - 2003/4/1
Y1 - 2003/4/1
N2 - Stroke is a treatable disease. Despite the therapeutic nihilism of the past, the advent of thrombolysis has changed the way stroke is approached. Acute ischemic stroke is a challenging and heterogeneous disease. Treatment needs to be based on an understanding of the underlying pathophysiology of ischemia. Interventions are designed to improve neuronal salvage and outcome. The underlying tenets of stroke therapy focus on the brain parenchyma, arterial flow (pipes), perfusion, the ischemic milieu or penumbra, and prevention of complications. This article focuses on the practical issues of ischemic stroke care, with a brief review of supporting literature.
AB - Stroke is a treatable disease. Despite the therapeutic nihilism of the past, the advent of thrombolysis has changed the way stroke is approached. Acute ischemic stroke is a challenging and heterogeneous disease. Treatment needs to be based on an understanding of the underlying pathophysiology of ischemia. Interventions are designed to improve neuronal salvage and outcome. The underlying tenets of stroke therapy focus on the brain parenchyma, arterial flow (pipes), perfusion, the ischemic milieu or penumbra, and prevention of complications. This article focuses on the practical issues of ischemic stroke care, with a brief review of supporting literature.
UR - http://www.scopus.com/inward/record.url?scp=0042235074&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0042235074&partnerID=8YFLogxK
U2 - 10.1097/01.SMJ.0000063573.56033.A6
DO - 10.1097/01.SMJ.0000063573.56033.A6
M3 - Review article
C2 - 12916550
AN - SCOPUS:0042235074
SN - 0038-4348
VL - 96
SP - 336
EP - 342
JO - Southern Medical Journal
JF - Southern Medical Journal
IS - 4
ER -