The absence of evidence of staphylococcal toxin involvement in the pathogenesis of kawasaki disease

Masaru Terai, Keishi Miwa, Tommy Williams, William Kabat, Mayumi Fukuyama, Yoshitomo Okajima, Hideo Igarashi, Stanford T. Shulman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

70 Scopus citations

Abstract

To detect a causative superantigen and to clarify a possible role for staphylococci in Kawasaki disease (KD), culture supernatants of individual bacterial isolates from 11 acute-stage patients were studied. Toxic shock syndrome toxin-1 (TSST-1) and antibody to TSST-1 and enterotoxins A (SEA), B (SEB), and C (SEC) in acute (mean, day 7) and late convalescent (mean, month 15) sera from 26 patients (12 with coronary artery aneurysms) and 22 age-matched controls were measured. Only 1 of 60 supernatants was mitogenic for human lymphocytes; it was 1 of the 4 Staphylococcus aureus isolates. Mitogenicity was neutralized by sera obtained after administration of intravenous gamma globulin (mean, week 4) but not by late convalescent sera. TSST-1 was detectable in 2 of 26 acute sera and 1 of 22 control sera. No KD but 1 control serum had IgM to TSST-1. IgG seroconversion rates to TSST-1, SEA, SEB, and SEC were 10%, 15%, 21%, and 16%, respectively. These data do not support the involvement of toxin-producing staphylococci in KD.

Original languageEnglish (US)
Pages (from-to)558-561
Number of pages4
JournalJournal of Infectious Diseases
Volume172
Issue number2
DOIs
StatePublished - Aug 1995

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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