The absence of evidence of staphylococcal toxin involvement in the pathogenesis of kawasaki disease

Masaru Terai, Keishi Miwa, Tommy Williams, William Kabat, Mayumi Fukuyama, Yoshitomo Okajima, Hideo Igarashi, Stanford T Shulman*

*Corresponding author for this work

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

To detect a causative superantigen and to clarify a possible role for staphylococci in Kawasaki disease (KD), culture supernatants of individual bacterial isolates from 11 acute-stage patients were studied. Toxic shock syndrome toxin-1 (TSST-1) and antibody to TSST-1 and enterotoxins A (SEA), B (SEB), and C (SEC) in acute (mean, day 7) and late convalescent (mean, month 15) sera from 26 patients (12 with coronary artery aneurysms) and 22 age-matched controls were measured. Only 1 of 60 supernatants was mitogenic for human lymphocytes; it was 1 of the 4 Staphylococcus aureus isolates. Mitogenicity was neutralized by sera obtained after administration of intravenous gamma globulin (mean, week 4) but not by late convalescent sera. TSST-1 was detectable in 2 of 26 acute sera and 1 of 22 control sera. No KD but 1 control serum had IgM to TSST-1. IgG seroconversion rates to TSST-1, SEA, SEB, and SEC were 10%, 15%, 21%, and 16%, respectively. These data do not support the involvement of toxin-producing staphylococci in KD.

Original languageEnglish (US)
Pages (from-to)558-561
Number of pages4
JournalJournal of Infectious Diseases
Volume172
Issue number2
DOIs
StatePublished - Jan 1 1995

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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