TY - JOUR
T1 - The absence of evidence of staphylococcal toxin involvement in the pathogenesis of kawasaki disease
AU - Terai, Masaru
AU - Miwa, Keishi
AU - Williams, Tommy
AU - Kabat, William
AU - Fukuyama, Mayumi
AU - Okajima, Yoshitomo
AU - Igarashi, Hideo
AU - Shulman, Stanford T.
N1 - Funding Information:
Received 5 December 1994; revised 9 March 1995. Informed consent was obtained from parents of patients. Financial support: Kawasaki Research Fund and Rogers Fellowship, Children's Memorial Hospital. Reprints or correspondence: Dr. Stanford T. Shulman, Division ofInfectious Diseases, Children's Memorial Hospital, 2300 Children's Plaza, Chicago, IL 60614.
PY - 1995/8
Y1 - 1995/8
N2 - To detect a causative superantigen and to clarify a possible role for staphylococci in Kawasaki disease (KD), culture supernatants of individual bacterial isolates from 11 acute-stage patients were studied. Toxic shock syndrome toxin-1 (TSST-1) and antibody to TSST-1 and enterotoxins A (SEA), B (SEB), and C (SEC) in acute (mean, day 7) and late convalescent (mean, month 15) sera from 26 patients (12 with coronary artery aneurysms) and 22 age-matched controls were measured. Only 1 of 60 supernatants was mitogenic for human lymphocytes; it was 1 of the 4 Staphylococcus aureus isolates. Mitogenicity was neutralized by sera obtained after administration of intravenous gamma globulin (mean, week 4) but not by late convalescent sera. TSST-1 was detectable in 2 of 26 acute sera and 1 of 22 control sera. No KD but 1 control serum had IgM to TSST-1. IgG seroconversion rates to TSST-1, SEA, SEB, and SEC were 10%, 15%, 21%, and 16%, respectively. These data do not support the involvement of toxin-producing staphylococci in KD.
AB - To detect a causative superantigen and to clarify a possible role for staphylococci in Kawasaki disease (KD), culture supernatants of individual bacterial isolates from 11 acute-stage patients were studied. Toxic shock syndrome toxin-1 (TSST-1) and antibody to TSST-1 and enterotoxins A (SEA), B (SEB), and C (SEC) in acute (mean, day 7) and late convalescent (mean, month 15) sera from 26 patients (12 with coronary artery aneurysms) and 22 age-matched controls were measured. Only 1 of 60 supernatants was mitogenic for human lymphocytes; it was 1 of the 4 Staphylococcus aureus isolates. Mitogenicity was neutralized by sera obtained after administration of intravenous gamma globulin (mean, week 4) but not by late convalescent sera. TSST-1 was detectable in 2 of 26 acute sera and 1 of 22 control sera. No KD but 1 control serum had IgM to TSST-1. IgG seroconversion rates to TSST-1, SEA, SEB, and SEC were 10%, 15%, 21%, and 16%, respectively. These data do not support the involvement of toxin-producing staphylococci in KD.
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U2 - 10.1093/infdis/172.2.558
DO - 10.1093/infdis/172.2.558
M3 - Article
C2 - 7622905
AN - SCOPUS:0029165958
VL - 172
SP - 558
EP - 561
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 2
ER -
