TY - JOUR
T1 - The acari hypothesis, ii
T2 - Interspecies operability of pattern recognition receptors
AU - Retzinger, Andrew C.
AU - Retzinger, Gregory S.
N1 - Funding Information:
Funding: This research was supported in part by funding to GSR from the Department of Pathology, Feinberg School of Medicine, Northwestern University.
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/9
Y1 - 2021/9
N2 - Hypersensitivity to galactose-α-1,3-galactose (α-gal) is an informative example of a pathologic IgE-mediated process. By way of their saliva, ticks are able to sensitize humans to tick dietary elements that express α-gal. Mites, which along with ticks constitute the phyletic subclass Acari, feed on proteinaceous foodstuffs that represent most, if not all, human allergens. Given: (1) the gross nature of the pathophysiological reactions of allergy, especially anaphylaxis, (2) the allergenicity of acarian foodstuffs, and (3) the relatedness of ticks and mites, it has been hypothesized that human-acarian interactions are cardinal to the pathogenesis of allergy. In this report, a means by which such interactions contribute to that pathogenesis is proposed.
AB - Hypersensitivity to galactose-α-1,3-galactose (α-gal) is an informative example of a pathologic IgE-mediated process. By way of their saliva, ticks are able to sensitize humans to tick dietary elements that express α-gal. Mites, which along with ticks constitute the phyletic subclass Acari, feed on proteinaceous foodstuffs that represent most, if not all, human allergens. Given: (1) the gross nature of the pathophysiological reactions of allergy, especially anaphylaxis, (2) the allergenicity of acarian foodstuffs, and (3) the relatedness of ticks and mites, it has been hypothesized that human-acarian interactions are cardinal to the pathogenesis of allergy. In this report, a means by which such interactions contribute to that pathogenesis is proposed.
KW - Acari hypothesis
KW - Fibrinogen-related protein (FReP)
KW - IgE
KW - Interspecies operability
KW - Ixoderin
KW - Mites
KW - Ticks
KW - Vector
UR - http://www.scopus.com/inward/record.url?scp=85115617391&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85115617391&partnerID=8YFLogxK
U2 - 10.3390/pathogens10091220
DO - 10.3390/pathogens10091220
M3 - Article
C2 - 34578252
AN - SCOPUS:85115617391
SN - 2076-0817
VL - 10
JO - Pathogens
JF - Pathogens
IS - 9
M1 - 1220
ER -
