TY - JOUR
T1 - The acidic glycosaminoglycans in human fetal development and adult life
T2 - Cornea, sclera and skin
AU - Breen, Moira
AU - Johnson, Ruth L.
AU - Sittig, R. A.
AU - Weinstein, H. G.
AU - Veis, Arthur
PY - 1972/1/1
Y1 - 1972/1/1
N2 - A comparison was made of the concentration and composition of the acidic glycosaminoglycans in human cornea, sclera and skin during five to nine months fetal development and in the adult. In skin, the concentration of the acidic glycosaminoglycans decreases gradually duringfetal development; the adult value is still less than the newborn; hyaluronic acid and dermatan sulfate are always present. In sclera, during the same period of development the concentration of the acidic glycosaminoglycans varied little; dermatan sulfate is the main component in both fetus and adult but the latter also contains some hyaluronic acid and chondroitin 4(6)-sulfate. The concentration of the acidic glycosaminoglycans in cornea increased by 33% at seven months gestation and remained constant; fetal cornea has chondroitin 4(6)-sulfate, chondroitin and a small amount of keratan sulfate (18 to 27% of the acidic glycosaminoglycans); in contrast, the adult cornea is rich in keratan sulfate (64 % of the acidic glycosaminoglycans) and contains more chondroitin and less chondroitin 4(6)-sulfate than fetal cornea. It is suggested that the organization of the collagen fibrils is functionally related to the nature of the acidic glycosaminoglycans associated with them.
AB - A comparison was made of the concentration and composition of the acidic glycosaminoglycans in human cornea, sclera and skin during five to nine months fetal development and in the adult. In skin, the concentration of the acidic glycosaminoglycans decreases gradually duringfetal development; the adult value is still less than the newborn; hyaluronic acid and dermatan sulfate are always present. In sclera, during the same period of development the concentration of the acidic glycosaminoglycans varied little; dermatan sulfate is the main component in both fetus and adult but the latter also contains some hyaluronic acid and chondroitin 4(6)-sulfate. The concentration of the acidic glycosaminoglycans in cornea increased by 33% at seven months gestation and remained constant; fetal cornea has chondroitin 4(6)-sulfate, chondroitin and a small amount of keratan sulfate (18 to 27% of the acidic glycosaminoglycans); in contrast, the adult cornea is rich in keratan sulfate (64 % of the acidic glycosaminoglycans) and contains more chondroitin and less chondroitin 4(6)-sulfate than fetal cornea. It is suggested that the organization of the collagen fibrils is functionally related to the nature of the acidic glycosaminoglycans associated with them.
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U2 - 10.3109/03008207209152087
DO - 10.3109/03008207209152087
M3 - Article
AN - SCOPUS:0000188422
VL - 1
SP - 291
EP - 303
JO - Connective Tissue Research
JF - Connective Tissue Research
SN - 0300-8207
IS - 4
ER -