The acute neurotoxicity and effects upon cholinergic axons of intracerebrally injected β-amyloid in the rat brain

M. Emre, C. Geula*, B. J. Ransil, M. M. Mesulam

*Corresponding author for this work

Research output: Contribution to journalArticle

120 Scopus citations

Abstract

The acute neurotoxicity and effects upon cholinergic axons of an intracerebrally injected synthetic peptide corresponding to the first 1-40 amino acids of beta-amyloid protein (βAP1-40) was studied in rats. A synthetic peptide with the reverse sequence (βAP40-1) or the vehicle alone were injected inthe contralateral hemisphere as control. The size of the resulting lesions was quantified in serial sections using an image analyzer. Counts of cholinergic and noradrenergic fibers were also obtained around the lesion area. The results revealed that βAP1-40 was significantly more toxic than both reverse peptide and the vehicle. The latter two, however, also caused considerable neurotoxicity. βAP1-40 was toxic to both cholinergic and noradrenergic fibers to the same extent, and this toxicity was limited to the immediate vicinity of the lesion. This study confirms and extends the results of previous studies reporting neurotoxic effects of intracerebrally injected beta-amyloid in the rat. Our results also show that βAP 1-40 itself is not the source of the altered acetylcholinesterase enzyme activity that has been described in the plaques and tangles of Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)553-559
Number of pages7
JournalNeurobiology of Aging
Volume13
Issue number5
DOIs
StatePublished - Jan 1 1992

Keywords

  • Alzheimer disease
  • Beta-amyloid
  • Cholinergic system

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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