TY - JOUR
T1 - The acute respiratory distress syndrome
T2 - From mechanism to translation
AU - Han, SeungHye
AU - Mallampalli, Rama K.
N1 - Publisher Copyright:
Copyright © 2015 by The American Association of Immunologists, Inc.
PY - 2015/2/1
Y1 - 2015/2/1
N2 - The acute respiratory distress syndrome (ARDS) is a form of severe hypoxemic respiratory failure that is characterized by inflammatory injury to the alveolar capillary barrier, with extravasation of protein-rich edema fluid into the airspace. Although many modalities to treat ARDS have been investigated over the past several decades, supportive therapies remain the mainstay of treatment. In this article, we briefly review the definition, epidemiology, and pathophysiology of ARDS and present emerging aspects of ARDS pathophysiology that encompass modulators of the innate immune response, damage signals, and aberrant proteolysis that may serve as a foundation for future therapeutic targets.
AB - The acute respiratory distress syndrome (ARDS) is a form of severe hypoxemic respiratory failure that is characterized by inflammatory injury to the alveolar capillary barrier, with extravasation of protein-rich edema fluid into the airspace. Although many modalities to treat ARDS have been investigated over the past several decades, supportive therapies remain the mainstay of treatment. In this article, we briefly review the definition, epidemiology, and pathophysiology of ARDS and present emerging aspects of ARDS pathophysiology that encompass modulators of the innate immune response, damage signals, and aberrant proteolysis that may serve as a foundation for future therapeutic targets.
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U2 - 10.4049/jimmunol.1402513
DO - 10.4049/jimmunol.1402513
M3 - Article
C2 - 25596299
AN - SCOPUS:84921473064
SN - 0022-1767
VL - 194
SP - 855
EP - 860
JO - Journal of Immunology
JF - Journal of Immunology
IS - 3
ER -