The acute respiratory distress syndrome: From mechanism to translation

SeungHye Han, Rama K. Mallampalli*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

259 Scopus citations


The acute respiratory distress syndrome (ARDS) is a form of severe hypoxemic respiratory failure that is characterized by inflammatory injury to the alveolar capillary barrier, with extravasation of protein-rich edema fluid into the airspace. Although many modalities to treat ARDS have been investigated over the past several decades, supportive therapies remain the mainstay of treatment. In this article, we briefly review the definition, epidemiology, and pathophysiology of ARDS and present emerging aspects of ARDS pathophysiology that encompass modulators of the innate immune response, damage signals, and aberrant proteolysis that may serve as a foundation for future therapeutic targets.

Original languageEnglish (US)
Pages (from-to)855-860
Number of pages6
JournalJournal of Immunology
Issue number3
StatePublished - Feb 1 2015

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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