The adenovirus major late transcription factor activates the rat γ-fibrinogen promoter

Lewis A. Chodosh*, Richard W. Carthew, John G. Morgan, Gerald R. Crabtree, Phillip A. Sharp

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

96 Scopus citations

Abstract

The major late transcription factor (MLTF) is a 46-kilodalton polypeptide that specifically binds to and activates transcription from the major late promoter of adenovirus. The presence of this promoter-specific transcription factor in uninfected HeLa cell extracts suggests that MLTF is also involved in the transcription of cellular genes. This report demonstrates that MLTF specifically stimulates transcription of the rat γ-fibrinogen gene through a high-affinity binding site. Stimulation of transcription by MLTF was not dependent on the exact position of the MLTF binding site with respect either to the transcription initiation site or to adjacent promoter elements. These results suggest that one of the cellular functions of MLTF is to control γfibrinogen gene expression.

Original languageEnglish (US)
Pages (from-to)684-688
Number of pages5
JournalScience
Volume238
Issue number4827
DOIs
StatePublished - 1987

ASJC Scopus subject areas

  • General

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