TY - JOUR
T1 - The Alveolar-Epithelial Barrier
T2 - A Target for Potential Therapy
AU - Budinger, G. R.Scott
AU - Sznajder, Jacob I.
PY - 2006/12
Y1 - 2006/12
N2 - Alveolar-capillary barrier dysfunction is a defining feature of acute lung injury. Evolving therapies developed in animal models of lung injury have resulted in the generation of an array of techniques, drugs, and novel small molecules that might protect patients who have acute lung injury by enhancing the function of the alveolar epithelial barrier. Some of these novel strategies are being tested in clinical trials. Investigators are optimistic that the completion of these trials will provide new, molecular-based therapies that will improve outcomes in patients who have lung injury.
AB - Alveolar-capillary barrier dysfunction is a defining feature of acute lung injury. Evolving therapies developed in animal models of lung injury have resulted in the generation of an array of techniques, drugs, and novel small molecules that might protect patients who have acute lung injury by enhancing the function of the alveolar epithelial barrier. Some of these novel strategies are being tested in clinical trials. Investigators are optimistic that the completion of these trials will provide new, molecular-based therapies that will improve outcomes in patients who have lung injury.
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U2 - 10.1016/j.ccm.2006.06.007
DO - 10.1016/j.ccm.2006.06.007
M3 - Review article
C2 - 17085253
AN - SCOPUS:33750516537
SN - 0272-5231
VL - 27
SP - 655
EP - 669
JO - Clinics in Chest Medicine
JF - Clinics in Chest Medicine
IS - 4
ER -