The American Society of Transplantation Consensus Conference on the Use of Hepatitis C Viremic Donors in Solid Organ Transplantation

J. Levitsky*, R. N. Formica, R. D. Bloom, M. Charlton, M. Curry, J. Friedewald, J. Friedman, D. Goldberg, S. Hall, M. Ison, T. Kaiser, D. Klassen, G. Klintmalm, J. Kobashigawa, A. Liapakis, K. O'Conner, P. Reese, D. Stewart, N. Terrault, N. TheodoropoulosJ. Trotter, E. Verna, M. Volk

*Corresponding author for this work

Research output: Contribution to journalArticle

150 Scopus citations

Abstract

The availability of direct-acting antiviral agents for the treatment of hepatitis C virus (HCV) infection has resulted in a profound shift in the approach to the management of this infection. These changes have affected the practice of solid organ transplantation by altering the framework by which patients with end-stage organ disease are managed and receive organ transplants. The high level of safety and efficacy of these medications in patients with chronic HCV infection provides the opportunity to explore their use in the setting of transplanting organs from HCV-viremic patients into non–HCV-viremic recipients. Because these organs are frequently discarded and typically come from younger donors, this approach has the potential to save lives on the solid organ transplant waitlist. Therefore, an urgent need exists for prospective research protocols that study the risk versus benefit of using organs for hepatitis C–infected donors. In response to this rapidly changing practice and the need for scientific study and consensus, the American Society of Transplantation convened a meeting of experts to review current data and develop the framework for the study of using HCV viremic organs in solid organ transplantation.

Original languageEnglish (US)
Pages (from-to)2790-2802
Number of pages13
JournalAmerican Journal of Transplantation
Volume17
Issue number11
DOIs
StatePublished - Nov 2017

Keywords

  • clinical decision-making
  • clinical research/practice
  • clinical trial design
  • donors and donation: donor-derived infections
  • education
  • infection and infectious agents
  • organ allocation
  • organ procurement and allocation
  • organ transplantation in general
  • viral: hepatitis C

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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    Levitsky, J., Formica, R. N., Bloom, R. D., Charlton, M., Curry, M., Friedewald, J., Friedman, J., Goldberg, D., Hall, S., Ison, M., Kaiser, T., Klassen, D., Klintmalm, G., Kobashigawa, J., Liapakis, A., O'Conner, K., Reese, P., Stewart, D., Terrault, N., ... Volk, M. (2017). The American Society of Transplantation Consensus Conference on the Use of Hepatitis C Viremic Donors in Solid Organ Transplantation. American Journal of Transplantation, 17(11), 2790-2802. https://doi.org/10.1111/ajt.14381