The anaphase-promoting complex mediates TGF-β signaling by targeting SnoN for destruction

Yong Wan, Xuedong Liu, Marc W. Kirschner*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

152 Scopus citations

Abstract

Degradation of SnoN is thought to play an important role in the transactivation of TGF-β responsive genes. We demonstrate that the anaphase-promoting complex (APC) is a ubiquitin ligase required for the destruction of SnoN and that the APC pathway is regulated by TGF-β. The destruction box of SnoN is required for its degradation in response to TGF-β signaling. Furthermore, the APC activator CDH1 and Smad3 synergistically regulate SnoN degradation. Under these circumstances, CDH1 forms a quaternary complex with SnoN, Smad3, and APC. These results suggest that APCCDH1 and SnoN play central roles in regulating growth through the TGF-β signaling system.

Original languageEnglish (US)
Pages (from-to)1027-1039
Number of pages13
JournalMolecular cell
Volume8
Issue number5
DOIs
StatePublished - Nov 21 2001

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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