The angiographic effect of ergonovine and nifedipine in coronary artery spasm

S. Rich, L. E. Ford, J. Al-Sadir

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

In a patient with variant angina, we have shown that the calcium-channel blocker nifedipine inhibits both spontaneous and ergonivine-induced coronary artery spasm. It had no effect, however, on the dose related diffuse vasoconstriction caused by ergonovine, suggesting two distinct responses of coronary arteries to ergonovine provocation. Nifedipine did not cause epicardial coronary artery dilatation, as did nitroglycerin, supporting the rationale of using both therapies together to treat coronary artery spasm.

Original languageEnglish (US)
Pages (from-to)1127-1130
Number of pages4
JournalCirculation
Volume62
Issue number5
DOIs
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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