The antigenicity of synthetic peptide fragments of lactate dehydrogenase C4

Thomas E. Wheat, Joyce A. Shelton, Victoria Gonzales-Prevatt, Erwin Goldberg*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Lactate dehydrogenase C4 (LDH-C4) is an antigenic protein found only in spermatozoa and the mature testis. Synthetic peptides containing the amino acid sequences of the C-subunit, designated MC5-15, MC97-110 and MC211-220, were each conjugated to the carrier proteins diphtheria toxoid or bovine serum albumin. Rabbits immunized with these peptide-carrier conjugates produced antibodies to the peptide that cross-reacted with native LDH-C4. These data support our map that identifies antigenic domains of LDH-C4. Such synthetic peptides will be useful in the design of a contraceptive vaccine.

Original languageEnglish (US)
Pages (from-to)1195-1199
Number of pages5
JournalMolecular Immunology
Volume22
Issue number10
DOIs
StatePublished - Oct 1985

ASJC Scopus subject areas

  • Immunology
  • Molecular Biology

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