Abstract
Lactate dehydrogenase C4 (LDH-C4) is an antigenic protein found only in spermatozoa and the mature testis. Synthetic peptides containing the amino acid sequences of the C-subunit, designated MC5-15, MC97-110 and MC211-220, were each conjugated to the carrier proteins diphtheria toxoid or bovine serum albumin. Rabbits immunized with these peptide-carrier conjugates produced antibodies to the peptide that cross-reacted with native LDH-C4. These data support our map that identifies antigenic domains of LDH-C4. Such synthetic peptides will be useful in the design of a contraceptive vaccine.
Original language | English (US) |
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Pages (from-to) | 1195-1199 |
Number of pages | 5 |
Journal | Molecular Immunology |
Volume | 22 |
Issue number | 10 |
DOIs | |
State | Published - Oct 1985 |
ASJC Scopus subject areas
- Immunology
- Molecular Biology