TY - JOUR
T1 - The antigenicity of synthetic peptide fragments of lactate dehydrogenase C4
AU - Wheat, Thomas E.
AU - Shelton, Joyce A.
AU - Gonzales-Prevatt, Victoria
AU - Goldberg, Erwin
PY - 1985/10
Y1 - 1985/10
N2 - Lactate dehydrogenase C4 (LDH-C4) is an antigenic protein found only in spermatozoa and the mature testis. Synthetic peptides containing the amino acid sequences of the C-subunit, designated MC5-15, MC97-110 and MC211-220, were each conjugated to the carrier proteins diphtheria toxoid or bovine serum albumin. Rabbits immunized with these peptide-carrier conjugates produced antibodies to the peptide that cross-reacted with native LDH-C4. These data support our map that identifies antigenic domains of LDH-C4. Such synthetic peptides will be useful in the design of a contraceptive vaccine.
AB - Lactate dehydrogenase C4 (LDH-C4) is an antigenic protein found only in spermatozoa and the mature testis. Synthetic peptides containing the amino acid sequences of the C-subunit, designated MC5-15, MC97-110 and MC211-220, were each conjugated to the carrier proteins diphtheria toxoid or bovine serum albumin. Rabbits immunized with these peptide-carrier conjugates produced antibodies to the peptide that cross-reacted with native LDH-C4. These data support our map that identifies antigenic domains of LDH-C4. Such synthetic peptides will be useful in the design of a contraceptive vaccine.
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U2 - 10.1016/0161-5890(85)90008-2
DO - 10.1016/0161-5890(85)90008-2
M3 - Article
C2 - 2417109
AN - SCOPUS:0021824553
SN - 0161-5890
VL - 22
SP - 1195
EP - 1199
JO - Molecular Immunology
JF - Molecular Immunology
IS - 10
ER -