The apoprotein B-independent hepatic uptake of chylomicron remnants

J. Borensztajn, G. S. Getz, R. J. Padley, T. J. Kotlar

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Rat lymph chylomicrons were treated with Pronase resulting in particles completely devoid of surface apoproteins. On re-incubation with serum, the Pronase-treated chylomicrons re-acquired, by transfer from other lipoproteins, all apoproteins except apoprotein B, which is water-insoluble and non-transferable. When two groups of rats were injected with [3H]cholesterol-labelled control or Pronase-treated chylomicrons, radioactivity was incorporated into the livers of both groups at similar rates. It is concluded that the remnants of the control and Pronase-treated chylomicrons formed in the vascular space were recognized and taken up by liver cells by a process that does not require apoprotein B.

Original languageEnglish (US)
Pages (from-to)609-612
Number of pages4
JournalBiochemical Journal
Issue number2
StatePublished - 1982

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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