TY - JOUR
T1 - The Ariel project
T2 - A prospective cohort study of maternal-child transmission of human immunodeficiency virus type 1 in the era of maternal antiretroviral therapy
AU - Van Dyke, Russell B.
AU - Korber, Bette T.
AU - Popek, Edwina
AU - Macken, Catherine
AU - Widmayer, Susan M.
AU - Bardeguez, Arlene
AU - Hanson, I. Celine
AU - Wiznia, Andrew
AU - Luzuriaga, Katherine
AU - Viscarello, Richard R.
AU - Wolinsky, Steven
AU - Ammann, Arthur
AU - Chen, Irvin
AU - Gifford, April
AU - Ho, David
AU - Koup, Richard A.
AU - Krogstad, Paul
AU - Muldoon, Mark
AU - Mulins, James
AU - Walker, Bruce
PY - 1999
Y1 - 1999
N2 - In a prospective cohort study, clinical and biologic factors that contribute to maternal-child transmission of human immunodeficiency virus type 1 (HIV-1) were studied. HIV-infected pregnant women and their infants were evaluated prospectively according to a standardized protocol. Of 204 evaluable women, 81% received zidovudine during their pregnancy. The infection rate among the 209 evaluable infants was 9.1%. By univariate analysis, histologic chorioamnionitis, prolonged rupture of membranes, and a history of genital warts were significantly associated with transmission. Additional factors associated with transmission that approached significance included a higher maternal virus load at delivery and the presence of cocaine in the urine. In a logistic regression model, histologic chorioamnionitis was the only independent predictor of transmission. Despite a significantly higher transmission rate at one site, no unique viral genotype was found at any site. Thus, chorioamnionitis was found to be the major risk factor for transmission among women receiving zidovudine.
AB - In a prospective cohort study, clinical and biologic factors that contribute to maternal-child transmission of human immunodeficiency virus type 1 (HIV-1) were studied. HIV-infected pregnant women and their infants were evaluated prospectively according to a standardized protocol. Of 204 evaluable women, 81% received zidovudine during their pregnancy. The infection rate among the 209 evaluable infants was 9.1%. By univariate analysis, histologic chorioamnionitis, prolonged rupture of membranes, and a history of genital warts were significantly associated with transmission. Additional factors associated with transmission that approached significance included a higher maternal virus load at delivery and the presence of cocaine in the urine. In a logistic regression model, histologic chorioamnionitis was the only independent predictor of transmission. Despite a significantly higher transmission rate at one site, no unique viral genotype was found at any site. Thus, chorioamnionitis was found to be the major risk factor for transmission among women receiving zidovudine.
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U2 - 10.1086/314580
DO - 10.1086/314580
M3 - Article
C2 - 9878014
AN - SCOPUS:0033053347
SN - 0022-1899
VL - 179
SP - 319
EP - 328
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 2
ER -
