The assessment and treatment of water imbalance in patients with psychosis

Research output: Contribution to journalReview article

21 Scopus citations

Abstract

Polydipsia and episodic life-threatening water intoxication remain important clinical problems for a significant portion of persons with schizophrenia. The disorders are associated with increased morbidity and mortality from a number of causes. With a basic understanding of the pathophysiology, one can easily diagnose and assess the clinical conditions. We review here the scope and pathophysiology of disordered water imbalance, including both primary and secondary polydipsia and hyponatremia. Reversible factors and possible interventions are reviewed. Treatment options for preventing water intoxication have expanded from discontinuation of offending agents, targeted fluid restriction, and clozapine therapy to the addition of oral vasopressin antagonists. The latter, however, are extremely potent and must be carefully monitored.

Original languageEnglish (US)
Pages (from-to)115-123
Number of pages9
JournalClinical Schizophrenia and Related Psychoses
Volume4
Issue number2
DOIs
StatePublished - Jul 1 2010

Keywords

  • Clozapine
  • Hyponatremia
  • Lithium
  • Polydipsia
  • Schizophrenia
  • Thiazide diuretics
  • Vasopressin
  • Water intoxication

ASJC Scopus subject areas

  • Medicine(all)
  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'The assessment and treatment of water imbalance in patients with psychosis'. Together they form a unique fingerprint.

  • Cite this