TY - JOUR
T1 - The association between nephroblastoma-specific outcomes and high versus low volume treatment centers
AU - Richards, Morgan K.
AU - Goldin, Adam B.
AU - Savinkina, Alexandra
AU - Doski, John
AU - Goldfarb, Melanie
AU - Nuchtern, Jed
AU - Langer, Monica
AU - Beierle, Elizabeth A.
AU - Vasudevan, Sanjeev
AU - Gow, Kenneth W.
AU - Raval, Mehul V
N1 - Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Background Though the volume-outcome relationship has been well-established in adults, low mortality rates and small sample sizes have precluded definitive demonstration in children. This study compares treatment-specific factors for children with nephroblastoma at high (HVC) versus low volume centers (LVC). Methods We performed a retrospective cohort study comparing patients ≤ 18 years with unilateral nephroblastoma treated at HVCs and LVCs using the National Cancer Data Base (1998–2012). Definitions of HVCs included performing above the median, the upper two quartiles, and the highest decile of nephroblastoma resections. Outcomes included nodal sampling, margin status, time to chemotherapy and radiation, and survival. Statistical analyses included χ2, t-tests, generalized linear, and Cox regression models (p < 0.05). Results Of 2911 patients from 210 centers, 1443 (49.6%) were treated at HVCs. There was no difference in frequency of preoperative biopsy or days to radiation (p > 0.05). High volume centers were more likely to perform nodal sampling (RR 1.04, 95%CI 1.01–1.08) and had fewer days to chemotherapy (RR 0.80, 95%CI 0.69–0.93). Five-year survival was similar (HVC: 0.93, 95%CI 0.92–0.94; LVC: 0.93, 95%CI 0.91–0.94). Conclusions HVCs were more likely to perform nodal sampling and had fewer days to chemotherapy. There was no difference in days to radiation or survival between centers. Level of evidence Level II (retrospective prognosis study).
AB - Background Though the volume-outcome relationship has been well-established in adults, low mortality rates and small sample sizes have precluded definitive demonstration in children. This study compares treatment-specific factors for children with nephroblastoma at high (HVC) versus low volume centers (LVC). Methods We performed a retrospective cohort study comparing patients ≤ 18 years with unilateral nephroblastoma treated at HVCs and LVCs using the National Cancer Data Base (1998–2012). Definitions of HVCs included performing above the median, the upper two quartiles, and the highest decile of nephroblastoma resections. Outcomes included nodal sampling, margin status, time to chemotherapy and radiation, and survival. Statistical analyses included χ2, t-tests, generalized linear, and Cox regression models (p < 0.05). Results Of 2911 patients from 210 centers, 1443 (49.6%) were treated at HVCs. There was no difference in frequency of preoperative biopsy or days to radiation (p > 0.05). High volume centers were more likely to perform nodal sampling (RR 1.04, 95%CI 1.01–1.08) and had fewer days to chemotherapy (RR 0.80, 95%CI 0.69–0.93). Five-year survival was similar (HVC: 0.93, 95%CI 0.92–0.94; LVC: 0.93, 95%CI 0.91–0.94). Conclusions HVCs were more likely to perform nodal sampling and had fewer days to chemotherapy. There was no difference in days to radiation or survival between centers. Level of evidence Level II (retrospective prognosis study).
KW - National Cancer Data Base
KW - Nephroblastoma
KW - Volume-outcome
KW - Wilms’ tumor
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U2 - 10.1016/j.jpedsurg.2016.10.029
DO - 10.1016/j.jpedsurg.2016.10.029
M3 - Article
C2 - 27836364
AN - SCOPUS:85009100520
SN - 0022-3468
VL - 52
SP - 104
EP - 108
JO - Journal of pediatric surgery
JF - Journal of pediatric surgery
IS - 1
ER -
