The association between pulmonary vascular disease and respiratory improvement in infants with type I severe bronchopulmonary dysplasia

Ryan J. Carpenter; Nina Srdanovic; Karen Rychlik; Shawn K. Sen; Nicolas F.M. Porta; Aaron E. Hamvas; Karna Murthy; Amanda L. Hauck

doi:10.1038/s41372-022-01386-6

The association between pulmonary vascular disease and respiratory improvement in infants with type I severe bronchopulmonary dysplasia

Ryan J. Carpenter^*, Nina Srdanovic, Karen Rychlik, Shawn K. Sen, Nicolas F.M. Porta, Aaron E. Hamvas, Karna Murthy, Amanda L. Hauck

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: To describe the association between echocardiographic measures of pulmonary vascular disease and time to respiratory improvement among infants with Type I severe bronchopulmonary dysplasia (sBPD). Study design: We measured the pulmonary artery acceleration time indexed to the right ventricular ejection time (PAAT/RVET) and right ventricular free wall longitudinal strain (RVFWLS) at 34-41 weeks’ postmenstrual age. Cox-proportional hazards models were used to estimate the relationship between the PAAT/RVET, RVFWLS, and the outcome: days from 36 weeks’ postmenstrual age to room-air or discharge with oxygen (≤0.5 L/min). Result: For 102 infants, the mean PAAT/RVET and RVFWLS were 0.27 ± 0.06 and −22.63 ± 4.23%. An abnormal measurement was associated with an increased time to achieve the outcome (PAAT/RVET: 51v24, p < 0.0001; RVFWLS; 62v38, p = 0.0006). A normal PAAT/RVET was independently associated with a shorter time to outcome (aHR = 2.04, 1.11–3.76, p = 0.02). Conclusion: The PAAT/RVET may aid in anticipating timing of discharge in patients with type I severe BPD.

Original language	English (US)
Pages (from-to)	788-795
Number of pages	8
Journal	Journal of Perinatology
Volume	42
Issue number	6
DOIs	https://doi.org/10.1038/s41372-022-01386-6
State	Published - Jun 2022

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynecology

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10.1038/s41372-022-01386-6

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title = "The association between pulmonary vascular disease and respiratory improvement in infants with type I severe bronchopulmonary dysplasia",

abstract = "Objective: To describe the association between echocardiographic measures of pulmonary vascular disease and time to respiratory improvement among infants with Type I severe bronchopulmonary dysplasia (sBPD). Study design: We measured the pulmonary artery acceleration time indexed to the right ventricular ejection time (PAAT/RVET) and right ventricular free wall longitudinal strain (RVFWLS) at 34-41 weeks{\textquoteright} postmenstrual age. Cox-proportional hazards models were used to estimate the relationship between the PAAT/RVET, RVFWLS, and the outcome: days from 36 weeks{\textquoteright} postmenstrual age to room-air or discharge with oxygen (≤0.5 L/min). Result: For 102 infants, the mean PAAT/RVET and RVFWLS were 0.27 ± 0.06 and −22.63 ± 4.23%. An abnormal measurement was associated with an increased time to achieve the outcome (PAAT/RVET: 51v24, p < 0.0001; RVFWLS; 62v38, p = 0.0006). A normal PAAT/RVET was independently associated with a shorter time to outcome (aHR = 2.04, 1.11–3.76, p = 0.02). Conclusion: The PAAT/RVET may aid in anticipating timing of discharge in patients with type I severe BPD.",

author = "Carpenter, {Ryan J.} and Nina Srdanovic and Karen Rychlik and Sen, {Shawn K.} and Porta, {Nicolas F.M.} and Hamvas, {Aaron E.} and Karna Murthy and Hauck, {Amanda L.}",

note = "Funding Information: Supported in part by the Stanley Manne Children{\textquoteright}s Research Institute and the Ann & Robert H. Lurie Children{\textquoteright}s Hospital of Chicago. Research Electronic Data Capture is supported at the Feinberg School of Medicine by the Northwestern University Clinical and Translational Science Institute. Research reported in this publication was supported, in part, by the National Institutes of Health{\textquoteright}s National Center for Advancing Translational Sciences, Grant Number UL1TR001422. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer Nature America, Inc.",

year = "2022",

month = jun,

doi = "10.1038/s41372-022-01386-6",

language = "English (US)",

volume = "42",

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T1 - The association between pulmonary vascular disease and respiratory improvement in infants with type I severe bronchopulmonary dysplasia

AU - Carpenter, Ryan J.

AU - Srdanovic, Nina

AU - Rychlik, Karen

AU - Sen, Shawn K.

AU - Porta, Nicolas F.M.

AU - Hamvas, Aaron E.

AU - Murthy, Karna

AU - Hauck, Amanda L.

N1 - Funding Information: Supported in part by the Stanley Manne Children’s Research Institute and the Ann & Robert H. Lurie Children’s Hospital of Chicago. Research Electronic Data Capture is supported at the Feinberg School of Medicine by the Northwestern University Clinical and Translational Science Institute. Research reported in this publication was supported, in part, by the National Institutes of Health’s National Center for Advancing Translational Sciences, Grant Number UL1TR001422. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Publisher Copyright: © 2022, The Author(s), under exclusive licence to Springer Nature America, Inc.

PY - 2022/6

Y1 - 2022/6

N2 - Objective: To describe the association between echocardiographic measures of pulmonary vascular disease and time to respiratory improvement among infants with Type I severe bronchopulmonary dysplasia (sBPD). Study design: We measured the pulmonary artery acceleration time indexed to the right ventricular ejection time (PAAT/RVET) and right ventricular free wall longitudinal strain (RVFWLS) at 34-41 weeks’ postmenstrual age. Cox-proportional hazards models were used to estimate the relationship between the PAAT/RVET, RVFWLS, and the outcome: days from 36 weeks’ postmenstrual age to room-air or discharge with oxygen (≤0.5 L/min). Result: For 102 infants, the mean PAAT/RVET and RVFWLS were 0.27 ± 0.06 and −22.63 ± 4.23%. An abnormal measurement was associated with an increased time to achieve the outcome (PAAT/RVET: 51v24, p < 0.0001; RVFWLS; 62v38, p = 0.0006). A normal PAAT/RVET was independently associated with a shorter time to outcome (aHR = 2.04, 1.11–3.76, p = 0.02). Conclusion: The PAAT/RVET may aid in anticipating timing of discharge in patients with type I severe BPD.

AB - Objective: To describe the association between echocardiographic measures of pulmonary vascular disease and time to respiratory improvement among infants with Type I severe bronchopulmonary dysplasia (sBPD). Study design: We measured the pulmonary artery acceleration time indexed to the right ventricular ejection time (PAAT/RVET) and right ventricular free wall longitudinal strain (RVFWLS) at 34-41 weeks’ postmenstrual age. Cox-proportional hazards models were used to estimate the relationship between the PAAT/RVET, RVFWLS, and the outcome: days from 36 weeks’ postmenstrual age to room-air or discharge with oxygen (≤0.5 L/min). Result: For 102 infants, the mean PAAT/RVET and RVFWLS were 0.27 ± 0.06 and −22.63 ± 4.23%. An abnormal measurement was associated with an increased time to achieve the outcome (PAAT/RVET: 51v24, p < 0.0001; RVFWLS; 62v38, p = 0.0006). A normal PAAT/RVET was independently associated with a shorter time to outcome (aHR = 2.04, 1.11–3.76, p = 0.02). Conclusion: The PAAT/RVET may aid in anticipating timing of discharge in patients with type I severe BPD.

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JO - Journal of Perinatology

JF - Journal of Perinatology

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ER -

The association between pulmonary vascular disease and respiratory improvement in infants with type I severe bronchopulmonary dysplasia

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