The association between systemic sclerosis disease manifestations and esophageal high-resolution manometry parameters

J. N. Kimmel, D. A. Carlson*, M. Hinchcliff, M. A. Carns, K. A. Aren, J. Lee, J. E. Pandolfino

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Background: We aimed to evaluate the associations between systemic sclerosis (SSc)-related systemic manifestations and esophageal function using high-resolution manometry (HRM). Methods: Patients with SSc that had undergone HRM between 1/2004 and 9/2014 were identified and HRMs were analyzed according to the Chicago Classification. Clinical characteristics were identified via retrospective chart review and compared among motility diagnoses while adjusting for age, gender, race, and SSc-disease duration. Key Results: Seventy-nine patients (85% female, ages 25–77) were included. Clinical characteristics were compared between patients with absent contractility (AC, n = 40), ineffective esophageal motility (IEM; n = 15), and normal motility (n = 19); the five remaining patients met criteria for other motility diagnoses. Groups differed in severity of skin involvement measured by the modified Rodnan skin score (0–51): AC (adjusted mean 12.6), IEM (4.4), normal (4.3), p = 0.043. Pulmonary function tests [percent predicted FVC and DLCO) were lower in AC (adjusted mean, FVC: 70.3, DLCO 51.1), than IEM (FVC: 92.0; DLCO: 76.9) and normal motility (FVC: 80.0; DLCO: 67.2), p values 0.057 (FVC) and 0.007 (DLCO). Groups did not differ by SSc-disease duration, autoantibodies, or reported symptoms of dysphagia or reflux. Conclusions & Inferences: In patients with SSc, absent esophageal contractility on HRM was associated with increased skin disease severity and worse lung function. Obtaining HRM to identify SSc patients with more severe esophageal dysfunction could be considered to enable implementation of management strategies in patients potentially at risk for increased morbidity and mortality.

Original languageEnglish (US)
Pages (from-to)1157-1165
Number of pages9
JournalNeurogastroenterology and Motility
Issue number8
StatePublished - Aug 1 2016


  • esophageal motility
  • high-resolution manometry
  • interstitial lung disease
  • modified Rodnan skin score
  • systemic sclerosis

ASJC Scopus subject areas

  • Physiology
  • Endocrine and Autonomic Systems
  • Gastroenterology


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