The association of serum C-reactive protein with the occurrence and course of postpartum depression

Emily S. Miller*, Denada Hoxha, Emily Pinheiro, William A. Grobman, Katherine L. Wisner

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

CRP has been positively correlated with depressive symptomatology but this has received less study in postpartum depression (PPD). In this secondary analysis of a trial of PPD treatment, depressive symptoms (Structured Interview Guide for the Hamilton Depression Rating Scale—Atypical Depression Symptoms (SIGH-ADS 29 )) and serum CRP levels were assessed and associations between CRP and SIGH-ADS 29 scores evaluated. The associations between baseline log CRP and depression response and remission were also assessed. Of the 35 women included, neither baseline log CRP nor exit log CRP was significantly associated with SIGH-ADS 29 score. Baseline CRP was not associated with response or remission. In this sample of women with PPD, CRP was not associated with depressive symptoms nor response to treatment.

Original languageEnglish (US)
Pages (from-to)129-132
Number of pages4
JournalArchives of Women's Mental Health
Volume22
Issue number1
DOIs
StatePublished - Feb 1 2019

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Keywords

  • C-reactive protein
  • CRP
  • Inflammation
  • Postpartum depression

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Psychiatry and Mental health

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