Efficient and practical: An aluminum-based catalyst system for the asymmetric Meerwein - Schmidt - Ponndorf - Verley reduction of aromatic ketones is reported. By using iPrOH as the achiral hydride source and BINOL-type chiral ligands (see scheme), chiral secondary aromatic alcohols (up to 83% ee) can be obtained in good yields.
|Original language||English (US)|
|Number of pages||3|
|Journal||Angewandte Chemie - International Edition|
|State||Published - Mar 15 2002|
- Asymmetric synthesis
- Homogeneous catalysis
ASJC Scopus subject areas