The asymmetric Meerwein - Schmidt - Ponndorf - Verley reduction of prochiral ketones with iPrOH catalyzed by Al catalysts

E. Joseph Campbell, Hongying Zhou, Son Binh T. Nguyen

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

Efficient and practical: An aluminum-based catalyst system for the asymmetric Meerwein - Schmidt - Ponndorf - Verley reduction of aromatic ketones is reported. By using iPrOH as the achiral hydride source and BINOL-type chiral ligands (see scheme), chiral secondary aromatic alcohols (up to 83% ee) can be obtained in good yields.

Original languageEnglish (US)
Pages (from-to)1020-1022
Number of pages3
JournalAngewandte Chemie - International Edition
Volume41
Issue number6
DOIs
StatePublished - Mar 15 2002

Keywords

  • Aluminum
  • Asymmetric synthesis
  • Homogeneous catalysis
  • Ketones
  • Reduction

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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