The asymmetric Meerwein - Schmidt - Ponndorf - Verley reduction of prochiral ketones with iPrOH catalyzed by Al catalysts

E. Joseph Campbell; Hongying Zhou; Son Binh T. Nguyen

doi:10.1002/1521-3773(20020315)41:6<1020::AID-ANIE1020>3.0.CO;2-S

The asymmetric Meerwein - Schmidt - Ponndorf - Verley reduction of prochiral ketones with iPrOH catalyzed by Al catalysts

E. Joseph Campbell, Hongying Zhou, Son Binh T. Nguyen

Chemistry

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Efficient and practical: An aluminum-based catalyst system for the asymmetric Meerwein - Schmidt - Ponndorf - Verley reduction of aromatic ketones is reported. By using iPrOH as the achiral hydride source and BINOL-type chiral ligands (see scheme), chiral secondary aromatic alcohols (up to 83% ee) can be obtained in good yields.

Original language	English (US)
Pages (from-to)	1020-1022
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	41
Issue number	6
DOIs	https://doi.org/10.1002/1521-3773(20020315)41:6<1020::AID-ANIE1020>3.0.CO;2-S
State	Published - Mar 15 2002

Keywords

Aluminum
Asymmetric synthesis
Homogeneous catalysis
Ketones
Reduction

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/1521-3773(20020315)41:6<1020::AID-ANIE1020>3.0.CO;2-S

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abstract = "Efficient and practical: An aluminum-based catalyst system for the asymmetric Meerwein - Schmidt - Ponndorf - Verley reduction of aromatic ketones is reported. By using iPrOH as the achiral hydride source and BINOL-type chiral ligands (see scheme), chiral secondary aromatic alcohols (up to 83% ee) can be obtained in good yields.",

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AU - Zhou, Hongying

AU - Nguyen, Son Binh T.

PY - 2002/3/15

Y1 - 2002/3/15

N2 - Efficient and practical: An aluminum-based catalyst system for the asymmetric Meerwein - Schmidt - Ponndorf - Verley reduction of aromatic ketones is reported. By using iPrOH as the achiral hydride source and BINOL-type chiral ligands (see scheme), chiral secondary aromatic alcohols (up to 83% ee) can be obtained in good yields.

AB - Efficient and practical: An aluminum-based catalyst system for the asymmetric Meerwein - Schmidt - Ponndorf - Verley reduction of aromatic ketones is reported. By using iPrOH as the achiral hydride source and BINOL-type chiral ligands (see scheme), chiral secondary aromatic alcohols (up to 83% ee) can be obtained in good yields.

KW - Aluminum

KW - Asymmetric synthesis

KW - Homogeneous catalysis

KW - Ketones

KW - Reduction

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The asymmetric Meerwein - Schmidt - Ponndorf - Verley reduction of prochiral ketones with iPrOH catalyzed by Al catalysts

Abstract

Keywords

ASJC Scopus subject areas

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