@article{677e5b89805f4caeb40d74c2b0e71863,
title = "The autophagy protein, FIP200 (RB1CC1) mediates progesterone responses governing uterine receptivity and decidualization",
abstract = "Successful establishment of pregnancy depends on steroid hormone-driven cellular changes in the uterus during the peri-implantation period. To become receptive to embryo implantation, uterine endometrial stromal cells (ESCs) must transdifferentiate into decidual cells that secrete factors necessary for embryo survival and trophoblast invasion. Autophagy is a key homeostatic process vital for cellular homeostasis. Although the uterus undergoes major cellular changes during early pregnancy, the precise role of autophagy in uterine function is unknown. Here, we report that conditional knockout of the autophagy protein FIP200 in the reproductive tract of female mice results in reduced fecundity due to an implantation defect. In the absence of FIP200, aberrant progesterone signaling results in sustained uterine epithelial proliferation and failure of stromal cells to decidualize. Additionally, loss of FIP200 impairs decidualization of human ESCs. We conclude that the autophagy protein FIP200 plays a crucial role in uterine receptivity, decidualization, and fertility. These data establish autophagy as a major cellular pathway required for uterine receptivity and decidualization in both mice and human ESCs.",
keywords = "PR-Cre, endometrium, fertility, hESCs, implantation, pregnancy",
author = "Oestreich, {Arin K.} and Chadchan, {Sangappa B.} and Alexandra Medvedeva and Lydon, {John P.} and Jungheim, {Emily S.} and Moley, {Kelle H.} and Ramakrishna Kommagani",
note = "Funding Information: ∗Correspondence: Ramakrishna Kommagani, PhD, Department of Obstetrics & Gynecology, Center for Reproductive Health Sciences, Washington University School of Medicine, BJC Institute of Health - 10th Floor, RM 10606, 425 S. Euclid Avenue Campus Box 8064, St. Louis MO 63110; Tel: (314) 273-1638; Fax: (314) 747-0264; E-mail: kommagani@wustl.edu; Kelle H. Moley, MD, Department of Obstetrics & Gynecology, Center for Reproductive Health Sciences, Washington University School of Medicine, BJC Institute of Health - 10th Floor, RM 10609, 425 S. Euclid Avenue Campus Box 8064, St. Louis MO 63110; Phone: (314) 362-1765; Fax: (314) 747-0264; E-mail: moleyk@wustl.edu †Grant Support: This work was supported by the following National Institutes of Health grants: NICHD R01 HD065435 and R01 HD083895 (to KHM), NICHD R01 HD065435 and R00-HD080742 (to RK), and T32 DK007120 (to AKO). ∗co-corresponding authors Funding Information: This work was supported by the following National Institutes of Health grants: NICHD R01 HD065435 and R01 HD083895 (to KHM), NICHD R01 HD065435 and R00HD080742 (to RK), and T32 DK007120 (to AKO). Publisher Copyright: {\textcopyright} 2020 The Author(s) 2020. Published by Oxford University Press on behalf of Society for the Study of Reproduction. All rights reserved.",
year = "2020",
month = apr,
day = "15",
doi = "10.1093/biolre/ioz234",
language = "English (US)",
volume = "102",
pages = "843--851",
journal = "Biology of Reproduction",
issn = "0006-3363",
publisher = "Society for the Study of Reproduction",
number = "4",
}