The BECN1-BCL2 complex regulates insulin secretion and storage in mice

Kenta Kuramoto, Congcong He*

*Corresponding author for this work

Research output: Contribution to journalComment/debatepeer-review

4 Scopus citations

Abstract

Macroautophagy/autophagy abnormality has been recently associated with metabolic disorders, such as type 2 diabetes (T2D). However, the effect of autophagy activation in systemic energy metabolism was poorly understood. In our recent study, we demonstrated that autophagy plays different roles in distinct metabolic tissues, using an autophagy-hyperactive mouse model. In insulin-producing β cells, excess autophagy degrades insulin-containing vesicles (a process termed vesicophagy), resulting in decreased insulin contents and systemic glucose intolerance; whereas in insulin-responsive cells, activating autophagy decreases endoplasmic reticulum (ER) stress and improves insulin sensitivity.

Original languageEnglish (US)
Pages (from-to)2026-2028
Number of pages3
JournalAutophagy
Volume14
Issue number11
DOIs
StatePublished - Nov 2 2018

Keywords

  • BECN1
  • ER stress
  • insulin granules
  • insulin sensitivity
  • type 2 diabetes
  • vesicophagy
  • β cell

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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