La reazione nera: una biotecnologia "cognitiva" ante litteram.

Translated title of the contribution: The black reaction: an ante litteram "cognitive" biotechnology

Mattia Quattrocelli*, Paolo Mazzarello

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The black reaction, also known nowadays as "Golgi staining" or "Golgi impregnation", paved the way to the development of modern neuroscience at the end of XIX century. By this staining, the silhouette of the nerve cell appears in all its morphological complexity with all its ramifications, which could be followed and analyzed even at a great distance from the cell body. However the reaction has been fundamental for discoveries in several other areas of biomedical research: cytology, myology, bacteriology. With the aid of the black reaction, for example, it was possible to observe: the Golgi apparatus, the T system related to the function of the sarcoplasmatic reticulum, the Müller-Golgi canaliculi of the peptic glands and many more; this wide and various success is due to its character of morphological amplification of fine structures. In spite of its still controversial biochemical nature, the black reaction has been an unavoidable versatile tool in different areas of biology, so we propose to consider this method as an ante litteram "cognitive" biotechnology.

Translated title of the contributionThe black reaction: an ante litteram "cognitive" biotechnology
Original languageItalian
Pages (from-to)19-28
Number of pages10
JournalMedicina nei secoli
Issue number1
StatePublished - Jan 1 2007

ASJC Scopus subject areas

  • Medicine(all)


Dive into the research topics of 'The black reaction: an ante litteram "cognitive" biotechnology'. Together they form a unique fingerprint.

Cite this