The Boosting Potential of Bacteria in Cancer Immunotherapy

David C. Binder, Derek A. Wainwright*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

4 Scopus citations

Abstract

Salmonella Typhimurium, engineered to express flagellin B, recently demonstrated unprecedented tumor control through a TLR-dependent mechanism. Here, we review new observations that support the potential of utilizing modified bacteria to enhance antitumor immunity. We also discuss the implications of these findings for clinical applications, including immune checkpoint blockade therapies.

Original languageEnglish (US)
Pages (from-to)580-582
Number of pages3
JournalTrends in Molecular Medicine
Volume23
Issue number7
DOIs
StatePublished - Jul 2017

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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