TY - JOUR
T1 - The building blocks for basolateral vesicles in polarized epithelial cells
AU - Folsch, Heike
PY - 2005/1/1
Y1 - 2005/1/1
N2 - After the discovery of basolateral sorting signals for polarized delivery in epithelial cells in the early 1990s, it was only about a decade later that the epithelial-cell-specific sorting adaptor AP-1B was discovered. AP-1B decodes a subclass of basolateral sorting signals and localizes to the recycling endosomes as opposed to the trans-Golgi network, suggesting that this is its major site of action. Furthermore, AP-1B does not simply select its cargo but also facilitates the recruitment of the exocyst complex needed for subsequent fusion with the plasma membrane. This review discusses our current knowledge of AP-1B function in cargo sorting to the basolateral membrane and its impact on our understanding of the similarities and differences between AP-1B-minus fibroblasts and AP-1B-positive epithelial cells.
AB - After the discovery of basolateral sorting signals for polarized delivery in epithelial cells in the early 1990s, it was only about a decade later that the epithelial-cell-specific sorting adaptor AP-1B was discovered. AP-1B decodes a subclass of basolateral sorting signals and localizes to the recycling endosomes as opposed to the trans-Golgi network, suggesting that this is its major site of action. Furthermore, AP-1B does not simply select its cargo but also facilitates the recruitment of the exocyst complex needed for subsequent fusion with the plasma membrane. This review discusses our current knowledge of AP-1B function in cargo sorting to the basolateral membrane and its impact on our understanding of the similarities and differences between AP-1B-minus fibroblasts and AP-1B-positive epithelial cells.
UR - http://www.scopus.com/inward/record.url?scp=16844374089&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=16844374089&partnerID=8YFLogxK
U2 - 10.1016/j.tcb.2005.02.006
DO - 10.1016/j.tcb.2005.02.006
M3 - Review article
C2 - 15817379
AN - SCOPUS:16844374089
VL - 15
SP - 222
EP - 228
JO - Trends in Cell Biology
JF - Trends in Cell Biology
SN - 0962-8924
IS - 4
ER -