The C. elegans gene lin-9, which acts in an Rb-related pathway, is required for gonadal sheath cell development and encodes a novel protein

Greg J. Beitel, Eric J. Lambie, H. Robert Horvitz*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

The Caenorhabditis elegans gene lin-9 functions in an Rb-related pathway that acts antagonistically to a receptor tyrosine kinase/Ras signal transduction pathway controlling vulval induction. We show that lin-9 is also required for the development of the sheath cells in the hermaphrodite gonad and for the development of the male spicule, rays and gonad. lin-9 is transcribed as two alternatively spliced 2.4 kb messages, which use two distinct polyadenylation sites and are SL1 trans-spliced. The conceptual translation of lin-9 cDNA sequences predicts proteins of 642 and 644 amino acids with a significant similarity to predicted Drosophila and vertebrate proteins. We suggest that lin-9 is the founding member of a new protein family that functions in Rb-related pathways in many species. (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)253-263
Number of pages11
JournalGene
Volume254
Issue number1-2
DOIs
StatePublished - Aug 22 2000

Keywords

  • Alternative splicing
  • Ras
  • Rb Cell fate
  • Signal transduction
  • Vulval induction

ASJC Scopus subject areas

  • Medicine(all)
  • Genetics

Fingerprint Dive into the research topics of 'The C. elegans gene lin-9, which acts in an Rb-related pathway, is required for gonadal sheath cell development and encodes a novel protein'. Together they form a unique fingerprint.

Cite this