The c-myc gene is a direct target of mammalian SWI/SNF-related complexes during differentiation-associated cell cycle arrest

Norman G. Nagl, Daniel R. Zweitzig, Bayar Thimmapaya, George R. Beck, Elizabeth Moran*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

86 Scopus citations

Abstract

The activity of mammalian SWI/SNF-related chromatin remodeling complexes is crucial for differentiation, development, and tumor suppression. Cell cycle-regulating activities dependent on the complexes include induction of the p21WAF1/CIP1 kinase inhibitor and repression of E2F-rcsponsive promoters. These responses are linked through effects on pRb phosphorylation, but the direct role of the SWI/SNF-related complexes in their regulation is not fully understood. Results presented here reveal that the complexes are required for regulation of a distinct pathway of proliferation control involving repression of c-myc expression in differentiating cells. This involves direct promoter targeting of the c-myc gene by the complexes. Induction of p21 WAF1/CIP1 is specifically dependent on prior repression of c-myc, but repression of E2F-responsive genes is dissociable from the regulation of c-myc and p21WAF1/CIP1.

Original languageEnglish (US)
Pages (from-to)1289-1293
Number of pages5
JournalCancer Research
Volume66
Issue number3
DOIs
StatePublished - Feb 1 2006

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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