The C-terminal domain of the largest subunit of RNA polymerase II and transcription initiation

M. Moyle, J. S. Lee, W. F. Anderson, C. J. Ingles*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Monoclonal antibodies specific for the evolutionarily conserved C-terminal heptapeptide repeat domain of the largest subunit of RNA polymerase II inhibited the initiation of transcription from mammalian promoters in vitro. Since these antibodies did not inhibit elongation and randomly initiated transcription, the heptapeptide repeats may function by binding class II transcription initiation factor(s).

Original languageEnglish (US)
Pages (from-to)5751-5753
Number of pages3
JournalMolecular and cellular biology
Volume9
Issue number12
DOIs
StatePublished - 1989

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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