The Caenorhabditis elegans gene lin-1 encodes an ETS-domain protein and defines a branch of the vulval induction pathway

Greg J. Beitel, Simon Tuck, Iva Greenwald, H. Robert Horvitz*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

128 Scopus citations

Abstract

The Caenorhabditis elegans gene lin-1 appears to act after the Ras-Raf- MEK-MAPK signaling cascade that mediates vulval induction. We show that lin- 1 is a negative regulator of vulval cell fates and encodes an ETS-domain putative transcription factor containing potential MAPK phosphorylation sites. In lin-1 null mutants, the vulval precursor cells (VPCs) still respond to signaling from the gonadal anchor cell, indicating that lin-1 defines a branch of the inductive signaling pathway. We also provide evidence that the inductive and lateral signaling pathways are integrated to control the 1° and 2° vulval cell fates after the point at which lin-1 acts in the inductive pathway and that VPCs can assess the relative rather than absolute levels of inductive and lateral signaling in determining whether to express the 1° or 2° vulval cell fates.

Original languageEnglish (US)
Pages (from-to)3149-3162
Number of pages14
JournalGenes and Development
Volume9
Issue number24
DOIs
StatePublished - Dec 15 1995

Keywords

  • C. elegans
  • ETS
  • cell fate
  • lin-1
  • signal transduction

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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