The caenorhabditis genetics center (CGC) and the caenorhabditis elegans natural diversity resource

Aric L. Daul, Erik C. Andersen, Ann E. Rougvie

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Research using C. elegans has led to fundamental insights into basic biological mechanisms, including the genetic basis of programmed cell death and cell signaling, the discovery of microRNAs, and the identification and subsequent elucidation of the mechanism of RNA interference in animals, and has been used to increase our understanding of the mechanisms of cancer progression and other diseases including Alzheimer’s and Parkinson’s. Caenorhabditis elegans is an androdioecious (hermaphrodite-male) species with a short generation time. The worms develop externally and are transparent, allowing observation of developmental events throughout an animal’s entire life history. The Caenorhabditis Genetics Center (CGC) was established in 1979 at the University of Missouri and subsequently moved to the University of Minnesota. During its first year in operation in MO, the center distributed a mere 15 strains. In 2013, 31,242 strains were shipped by the CGC. The CG Center’s collection contains ~20,700 genetically distinct strains of C. elegans in addition to more than 40 species in the genus. The work of the CGC is complemented by the activities of Wormbase, WormAtlas, and the Caenorhabditis elegans Natural Diversity Resource.

Original languageEnglish (US)
Title of host publicationThe Biological Resources of Model Organisms
PublisherCRC Press
Pages69-94
Number of pages26
ISBN (Electronic)9781351587778
ISBN (Print)9781138294615
StatePublished - Jan 1 2019

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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  • Cite this

    Daul, A. L., Andersen, E. C., & Rougvie, A. E. (2019). The caenorhabditis genetics center (CGC) and the caenorhabditis elegans natural diversity resource. In The Biological Resources of Model Organisms (pp. 69-94). CRC Press.